中国药物警戒 ›› 2026, Vol. 23 ›› Issue (4): 368-374.
DOI: 10.19803/j.1672-8629.20260138

• 高原睡眠-觉醒障碍的病证结合动物模型与中药干预研究专栏 • 上一篇    下一篇

高原睡眠障碍动物模型的构建与评价研究进展

陈熙泰1,2, 马增春1,2,*, 张娴勰1,2#, 戚凌1,2, 李芳1,2, 陈丽苹2, 拓艳玲2, 李舒曼2, 高亮3   

  1. 1广东药科大学药学院,广东 广州 510006;
    2军事科学院军事医学研究院,北京 100850;
    3陆军第950医院高原病科,新疆 叶城 844900
  • 收稿日期:2026-02-12 出版日期:2026-04-15 发布日期:2026-04-15
  • 通讯作者: *马增春,男,博士,副研究员,中药药理与毒理学。E-mail: mazchun@139.com。#为共同通信作者。
  • 作者简介:陈熙泰,男,在读硕士,药学。
  • 基金资助:
    国家自然科学基金资助项目（82474196）; 中医药能力提升项目（2023ZY063）

Research Progress in Establishment and Evaluation of Animal Models of High Altitude Sleep Disorders

CHEN Xitai1,2, MA Zengchun1,2,*, ZHANG Xianxie2#, QI Ling1,2, LI Fang1,2, CHEN Liping2, TA Yanling2, LI Shuman2, GAO Liang3   

  1. 1School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou Guangdong 510006, China;
    2Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China;
    3High Altitude Disease Department, the 950 th Hospital of PLA, Yecheng Xinjiang 844900, China
  • Received:2026-02-12 Online:2026-04-15 Published:2026-04-15

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摘要： 目的 回顾近年来睡眠障碍动物模型及其评测技术的研究,总结高原睡眠障碍动物模型的研究现状,为高原睡眠障碍动物模型的进一步研究提供参考。方法 检索中国知网、PubMed、Elsevier等数据库中关于睡眠障碍动物模型以及动物睡眠评测技术的研究文献,并对研究中使用的动物种类、模型构建方法与原理等进行归纳分析。结果 睡眠障碍动物模型通常选择啮齿类动物,包括SD大鼠、C57BL/6小鼠和KM小鼠,通过药物诱导、睡眠剥夺和应激刺激等方法构建,各种方法构建的模型具有不同的生理病理特点,对高原睡眠障碍动物模型的进一步研究有一定的参考价值。目前高原睡眠障碍动物模型主要依赖低压低氧暴露的方法构建,难以全面模拟高原睡眠障碍复杂的病理状态。针对睡眠障碍的不同证候分型,睡眠障碍病证结合动物模型通常选择啮齿类动物采用不同的多因素复合方法构建,实验对象主要为啮齿类动物,病证结合动物模型为高原睡眠障碍动物模型的构建开辟了新的思路。睡眠障碍动物模型评测技术的持续发展,为睡眠障碍的病理机制解析及干预效果评估提供技术支撑。结论 高原睡眠障碍动物模型有待深入研究,建立符合高原睡眠障碍临床实际的动物模型与评价标准,对推动高原睡眠障碍防治药物研发,保障高原地区人群健康具有重要价值。

关键词: 高原, 睡眠障碍, 动物模型构建, 病证结合动物模型, 大鼠, 小鼠

Abstract: Objective To review recent research on the establishment and evaluation of animal models of sleep disorders and related assessment techniques, and summarize the latest research findings on animal models of high-altitude sleep disorders so as to provide a reference for subsequent studies. Methods Literature on animal models of sleep disorders and animal sleep evaluation techniques was retrieved from such databases as CNKI, PubMed, and Elsevier before being analyzed in terms of animal species, model construction methods and principles employed. Results Rodents, including SD rats, C57BL/6J mice, and KM mice, are commonly selected to establish animal models of sleep disorders that are usually constructed via pharmacological induction, sleep deprivation, and stress stimulation. Each of these models has distinct physiopathological characteristics and provides an important reference. Currently, animal models of highaltitude sleep disorders are primarily established using hypobaric hypoxia exposure, which fails to fully replicate the complex pathological state of these disorders. For different syndrome patterns of sleep disorders, diseasesyndrome combination animal models are typically established using various multifactor composite approaches, with rodents serving as the primary experimental subjects. These models can open new avenues for the construction of highaltitude sleep disorder animal models. The constant development of evaluation techniques for animal models of sleep disorders provides technical support for the analysis of the pathological mechanisms of sleep disorders and the assessment of intervention effects. Conclusion More in-depth research is required on animal models of high-altitude sleep disorders. The availability of animal models and evaluation standards that reflect the clinical reality of high-altitude sleep disorders is essential for advancing the research and development of preventive and therapeutic drugs and for safeguarding the health of populations in high-altitude regions.

Key words: High-Altitude, Sleep Disorders, Animal Model Establishment, Disease-Syndrome Combination Animal Models, Rat, Mice

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