前胡的一般概况及质量形成因素浅析

doi:10.19803/j.1672-8629.20240255

摘要/Abstract

摘要： 目的系统阐述前胡药用的历史、化学成分、药理药效、产区分布、市场需求及质量控制等内容,为前胡药材的进一步开发利用和质量控制的提升提供参考。方法依据现有研究报道,系统梳理前胡药用历史沿革及其关键化学成分分布特征,阐述在现代化学和药理学理论基础下,前胡的传统药效与现代药理效用特征。结合文献,对前胡药材的道地产区、主要种植地域、市场需求量及产量进行全面分析。在此基础上,综合探讨前胡的标准现状及质量情况,并分析其质量的主要影响因素。结果前胡药用历史悠久且药理活性丰富,简单香豆素、呋喃香豆素、吡喃香豆素是其主要化学成分,浙江、安徽、江西为前胡药材主要道地产区,在重庆、贵州等地均有大规模种植。目前市场上以家种和仿野生品为主,野生资源逐渐变少。白花前胡乙素是其质量评价不合格的主要原因;白花前胡甲素和白花前胡乙素2个指标显示,环境地理、抽薹、不同形态等是影响前胡质量的主要因素。结论本文分析前胡药材多个方面,揭示了其基本概况及质量形成因素,对于推动前胡药材的可持续利用和产业发展具有一定意义。

关键词: 前胡, 质量评价, 白花前胡甲素, 白花前胡乙素, 简单香豆素, 呋喃香豆素, 质量标准, 道地产区

Abstract: Objective To describe the history of the medicinal use of Peucedanum Praeruptorum Dunn (PD), its chemical composition, efficacy, areas of production, market demands and quality control and to provide reference for its development, utilization and quality control. Methods Based on the reports available, the medicinal use of PD and its key chemical constituents were traced, and the traditional and modern pharmacology of PD was elaborated in terms of chemistry and pharmacology. The areas of production, chief planting areas, market demands and production of PD were analyzed. The current standard for PD and problems with the quality were discussed. Results PD had a long history of medicinal use and plenty of pharmacological activities, whose chemical components included simple coumarin, furan coumarin and pyranocoumarin. Zhejiang, Anhui and Jiangxi were important areas of production of PD. There was large-scale cultivation in Chongqing, Guizhou and elsewhere. The current market was dominated by domestic species and simulated wild products, and the wild resources were diminishing. The main reason for defects of the product was the presence of Praeruptorin B. Analysis of Praeruptorin A and Praeruptorin B suggested that environmental geography, extraction, and different morphologies made a huge difference to the quality of PD. Conclusion The basic profile and determinants of quality of PD have been explored. It is of great significance to promote the sustainable use and industrial development of the plant.

Key words: Peucedanum Praeruptorum Dunn, Quality Control, Praeruptorin A, Praeruptorin B, Simple Coumarin, Furan Coumarin, Quality Standard, Production Areas

中图分类号:

李耀磊, 金红宇, 魏锋, 马双成. 前胡的一般概况及质量形成因素浅析[J]. 中国药物警戒, 2024, 21(11): 1315-1320.

LI Yaolei, JIN Hongyu, WEI Feng, MA Shuangcheng. Introduction and Quality Factors of Peucedanum Praeruptorum Dunn[J]. Chinese Journal of Pharmacovigilance, 2024, 21(11): 1315-1320.

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参考文献

[1] YE L, FAN S, ZHAO P, et al.Potential Herb-Drug Interactions Between Anti-COVID-19 Drugs and Traditional Chinese Medicine[J]. Acta Pharmaceutica Sinica B, 2023, 13(9): 3598-3637.
[2] WANG Q, SUN Q, HUANG Q, et al.The Traditional Uses, Pharmacology, and Phytochemistry of Peucedanum Praeruptorum Dunn[J]. Front Pharmacol, 2024, 15(10): 1352657.
[3] LIANG T, HONG J, SHANG Z.The Record of Famous Doctors(名医别录)[M]. Beijing: People’s Health Publishing House, 1986: 122.
[4] SONG Z, LI B, TIAN K, et al.Research Progress on Chemical Constituents and Pharmacological Activities of Peucedani Radix and Peucedani Decursivi Radix[J]. Chinese Herbal Medicine(中草药), 2022, 53(3): 948-964.
[5] Chinese Pharmacopoeia Commission.Pharmacopoeia of the People’s Republic of China,Volume I(中华人民共和国药典一部)[M]. Beijing: China Medical Science Press, 1963: 178.
[6] Chinese Pharmacopoeia Commission.Pharmacopoeia of the People’s Republic of China,Volume I(中华人民共和国药典一部)[M]. Beijing: China Medical Science Press, 2005: 187.
[7] Chinese Pharmacopoeia Commission.Pharmacopoeia of the People’s Republic of China,Volume I(中华人民共和国药典一部)[M]. Beijing: China Medical Science Press, 2010: 248, 317-318.
[8] Chinese Pharmacopoeia Commission.Pharmacopoeia of the People’s Republic of China,Volume I(中华人民共和国药典一部)[M]. Beijing: China Medical Science Press, 2020: 277, 352.
[9] ZHAI X, WANG K, GAO X, et al.Research Progress on Chemical Constituents and Pharmacological Activities of Menispermi Rhizoma[J]. Molecules, 2023, 28(6): 2701.
[10] LSHI H, OKADA Y, BABA M, et al.Sudies of Coumarins From The Chinese Drug Qianhu, XXv/l: Structure of A New Simple Coumarin Aivcoside From Bai-Hua Qianhu, Peucedanum Praeruptorum[J]. Chem Pharm Bull, 2008, 56(9): 1349-1351.
[11] LIU RM, SUN QH, SHI YR, et al.Isolation and Purification of Coumarin Compounds from the Root of Peucedanum Decursivum (Miq.) Maxim by High-Speed Counter-Current Chromatography[J]. Journal of Chromatography A, 2005, 1076(112): 127-132.
[12] XU G, TAN Q, YANG D, et al.Effect of Index Components in Peucedanum Praerupterum by Different Extraction Methods[J]. Asia-Pacific Traditional Medicine(亚太传统医药), 2022, 18(3): 42-44.
[13] XU J, KONG L.Studies on the Chemical Composition of the Stem and Leaf of Pseudostellaria Pinnatifida[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2001, 26(3): 178-180.
[14] KONG LY, LI M, PEI YH, et al.Studies on the Chemical Composition of Radix et Rhizoma Pinelliae (V)[J]. Chinese Herbal Medicine(中草药), 1993, 24(8): 401-404.
[15] CHEN Z, HUANG B, YU Q, et al.Studies on the Chemical Constituents of the Traditional Chinese Medicine, Radix et Rhizoma Pinelliae: the Structures of Four New Coumarins[J]. Acta Pharmaceutica Sinica(药学学报), 1979, 14(8): 486-496.
[16] ZHANG C, XIAO Y, LI L, et al.A Study on Chemical Components of Peucedanum Praeruptorum Dunn (V)[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2012, 37(23): 3573-3576.
[17] YU N, LIU S, LIANG Y, et al.A Comparsion of Chemical Components of Volatile Oils from the Decocting Pieces of Peucedanum Praeruptorum in Different Regions[J]. Journal of Anhui University of Chinese Medicine(安徽中医学院学报), 2007, 26(1): 44-45.
[18] LEI H, ZOU S, ZHANG H, et al.Compositional Analysis of the Volatile Oils of Three Species of Piper Betulae[J]. Journal of Chinese Medicinal Materials(中药材), 2016, 39(4): 795-798.
[19] ZHEN Q, SHANG Z.Theory of Pharmacognosy-Classification of Pharmacognosy Tendencies(药性论)[M]. Anhui Science and Technology Press, 2006.
[20] LAN M. Yunnan Materia Medica(滇南本草)[M]. Kunming: Yunnan Science and Technology Press, 2008.
[21] LI SZ.Compendium of Materia Medica(本草纲目)[M]. Nanchang: Twenty-first Century Press, 2014.
[22] LIU Y, DING Y, LI L.Explaination of the Jiangqihuatan Efficacy of Peucedanum Praeruptorum Dunn Based on Network Pharmacology[J]. Guangdong Chemical Industry(广东化工), 2023, 50(6): 174-177, 146.
[23] LI G, ZHANG L, ZOU J, et al.Protective effects of Peucedanum Praeruptorum Dunn on Acute Myocardial Ischemia in Mice and Rats[C]. Editorial Department of Chinese Pharmacological Bulletin(中国药理学会第十次全国学术会议专刊), 2009.
[24] TU X, WANG J, TU Q, et al.Effects of Peucedanum Praeruptorum Dunn Extract on Left Ventricular Remodeling and Bcl-2, Bax Protein Expression in Aorta Coarctation Rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics(中国临床药理学与治疗学), 2004, 9(4): 394-398.
[25] PARK J, KIM J, SHIN J, et al.Anti-inflammatory Effects of Peucedanum Japonicum Thunberg Leaves Extract in Lipopolysaccharide-stimulated RAW264.7 cells[J]. Journal of Ethnopharmacology, 2023, 309(10): 116362.
[26] PARK H, JEONG J, PARK S.The Root Extract of Peucedanum Praeruptorum Dunn Exerts Anticancer Effects in Human Non-small-Cell Lung Cancer cells with Different EGFR Mutation Statuses by Suppressing MET Activity[J]. Molecules, 2022, 27(7): 2360.
[27] LIAO G, DUAN J, LIN J.The Effect of Peucedunum Extracts on Monoamine Transmitter in Brain Tissues in Rats with Depression[J]. Strait Pharmaceutical Journal(海峡药学), 2016, 28(7): 17-20.
[28] XIONG YY, WU FH, WANG JS, et al.Attenuation of Airway Hyperreactivity and T Helper Cell Type 2 Responses by Coumarins from Peucedanum Praeruptorum Dunn in A Murine Model of Allergic Airway Inflammation[J]. Journal of Ethnopharmacology, 2012, 141(1): 314-321.
[29] YU CL, YU YL, YANG SF, et al.Praeruptorin A Reduces Metastasis of Human Hepatocellular Carcinoma Cells by Targeting ERK/MMP1 Signaling Pathway[J]. Environmental Toxicology, 2021, 36(4): 540-549.
[30] WU MH, LIN CL, CHIOU HL, et al.Praeruptorin A Inhibits Human Cervical Cancer Cell Growth and Invasion by Suppressing MMP-2 Expression and ERK1/2 Signaling[J]. International Journal of Molecular Sciences, 2017, 19(1): 10.
[31] CHEN Q, LIU X, PAN L, et al.Study on the Effects of Praeruptorin A Combined with Low Concentration of Taxol on Taxol-resistant Ovarian Cancer Cell Line A2780/TAX[J]. Chinese Journal of Hospital Pharmacy(中国医院药学杂志), 2022, 42(17): 1755-1759, 1765.
[32] LI Z, ZHANG F, WANG S, et al.Endothelium-Dependent Vasorelaxant Effects of Praeruptorin a In Isolated Rat Thoracic Aorta[J]. Bioengineered, 2022, 13(4): 10038-10046.
[33] XU Z, WANG X, DAI Y, et al.(+/-)-Praeruptorin A Enantiomers Exert Distinct Relaxant Effects on Isolated Rat Aorta Rings Dependent on Endothelium and Nitric Oxide Synthesis[J]. Chemico-Biological Interactions, 2010, 186(2): 239-246.
[34] QIU QH.Protective Effect of White-Flowered Prenylidenol Against Cerebral Ischaemia-Reperfusion in Rats by Regulating the Expression of Bcl-2/Bax, Caspase9 and Caspase3[D]. Fuzhou: Fujian Medical University(福建医科大学), 2017.
[35] GUAN F, JIN W, ZHANG X, et al.The Effects of Praeruptorin a on the Contraction of Isolated Tracheal Smooth Muscle Previously Induced by High k and Acetylcholine[J]. Journal of China Medical University(中国医科大学学报), 1994, 23(6): 549-552.
[36] HU J, LIU R, YANG Z, et al.Praeruptorin A Inhibits the Activation of NF-κB Pathway and the Expressions of Inflammatory Factors in Poly (I:C)-induced RAW264.7 Cells[J]. Chemical Biology & Drug Design, 2023, 102(5): 1110-1120.
[37] YU PJ, CI W, WANG GF, et al.Praeruptorin A Inhibits Lipopolysaccharide-Induced Inflammatory Response in Murine Macrophages Through Inhibition of NF-κB Pathway Activation[J]. Phytotherapy Research: PTR, 2011, 25(4): 550-556.
[38] YEON JT, CHOI SW, RYU BJ, et al.Praeruptorin A Inhibits In Vitro Migration of Preosteoclasts and In Vivo Bone Erosion, Possibly Due to Its Potential to Target Calmodulin[J]. Journal of Natural Products, 2015, 78(4): 776-782.
[39] XU K, CHEN Z, HOU J, et al.Praeruptorin B Inhibits Osteoclastogenesis by Targeting GSTP1 and Impacting on the S-glutathionylation of IKKβ[J]. Biomedicine & Pharmacotherapy, 2022, 154(26): 113529.
[40] ZHENG ZG, LU C, THU PM, et al.Correction: Praeruptorin B Improves Diet-Induced Hyperlipidemia and Alleviates Insulin Resistance Via Regulating SREBP Signaling Pathway[J]. RSC Advances, 2019, 9(11): 6101.
[41] LIN CL, HUNG TW, YING TH, et al.Praeruptorin B Mitigates the Metastatic Ability of Human Renal Carcinoma Cells Through Targeting CTSC and CTSV Expression[J]. International Journal of Molecular Sciences, 2022, 21(8): 2919.
[42] OZAKI H, NISHIDONO Y, FUJII A, et al.Identification of Anti-Inflammatory Compounds from Peucedanum Praeruptorum Roots by Using Nitric Oxide-Producing Rat Hepatocytes Stimulated by Interleukin 1β[J]. Molecules, 2023, 28(13): 5076.
[43] XUE NM, CHAI MY, YANG WS, et al.Inhibitory Effect of Praeruptorin B on SK-OV-3 Cell Proliferation in Ovari-an Cancer by SREBP-1 c/FASN Signaling Pathway[J]. Chinese Journal of Gerontology(中国老年学杂志), 2021, 41(13): 2773-2777.
[44] Editorial Committee of Flora of China, Chinese Academy of Sciences. Flora of China(中国植物志)[M]. Beijing: Science Press, 2004.
[45] Chinese Society of Traditional Chinese Medicine (CSTCM). Taoist Medicinal Herbs - Part 88: Xinqianhu (T/CACM 1020.88-2019)[S]. 2019.
[46] LIU J, WANG S, LI X, et al.Investigation and Analysis on the Present Situation of Peucedanum Praeruptorum Resources in its Producing area[J]. Modern Agricultural Science and Technology(现代农业科技), 2021, 1(1): 89-92, 99.
[47] XIONG YX, CHEN KL, LIU YM, et al.Survey on the resources of the Medicinal Plant Pseudourostyla Cristata[J]. Lishizhen Medicine and Materia Medica(时珍国医国药), 2013, 24(11): 2786-2789.
[48] SHI T, ZHANG X, ZHANG K, et al.Study of Extracting Peucedanum Praeruptorum Planted Area in Ningguo of Anhui Province Based on multi-source and multi-phase image[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2017, 42(22): 4362-4367.
[49] Group Standard.Commodity Specification Grade of Chinese Herbal Medicines-Qianhu (T/CACM 1021.74-2018)[S]. Beijing, Chinese Society of Traditional Chinese Medicine, 2018.
[50] LIU TL, JIANG V, SHU GP, et al.Visual Analysis of Research Hotspots and Trends and Research on Origin and Market of Peucedani Radix[J].Chinese Herbal Medicine(中草药), 2022, 53(24): 7855-7863.
[51] LUO M, XU G, TAN QS, et al.Response of Medicinal Quality to Altitude Gradient in Peucedanum Praeruptorum Dunn[J]. Chinese Wild Plant Resources(中国野生植物资源), 2022, 41(11): 20-24.
[52] YANG L, KANG X, DU W, et al.Effect of Altitude of Producing Area on Contents of Praeruptorin A and Praeruptorin B in Qianhu(Peucedani Radix)[J]. Chinese Archives of Traditional Chinese(中华中医药学刊), 2021, 39(8): 14-18.
[53] LIANG W, HU Y, PU J, et al.Correlation Analysis Between Active Ingredients Contents and Soil Factors in Peucedani Radix[J]. Chinese Journal of Modern Applied Pharmacy(中国现代应用药学), 2021, 38(11): 1302-1308.
[54] XU P, ZHANG G, YU Y, et al.Effects of Cultivation Methods on Growth and Quality of Peucedani Radix[J]. Modern Chinese Medicine(中国现代中药), 2023, 25(3): 559-567.
[55] SONG C, LI X, JIA B, et al.Comparative Transcriptomics Unveil the Crucial Genes Involved in Coumarin Biosynthesis in Peucedanum Praeruptorum Dunn[J]. Frontiers in Plant Science, 2022, 13(17): 899819.
[56] WANG ZW, ZHANG YF, LU J, et al.Study on the Main Biological Characteristics and Growth and Development Pattern of the White-Flowered Radix et Rhizoma Pinelliae L.[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2007, 32(2): 145-146.
[57] SHI X, HUANG Q, GUO Z, et al.Study on the Key Factors Affecting the Quality of Peucedani Radix[J]. Chinese Journal of Modern Applied Pharmacy(中国现代应用药学), 2022, 39(2): 192-195.
[58] XIE J, TANG X, XIE C, et al.Comparative Analysis of Root Anatomical Structure, Chemical Components and Differentially Expressed Genes Between Early Bolting and Unbolting in Peucedanum Praeruptorum Dunn[J]. Genomics, 2023, 115(2): 110557.
[59] CHU S, CHEN L, XIE H, et al.Comparative Analysis and Chemical Profiling of Different forms of Peucedani Radix[J]. Journal of Pharmaceutical and Biomedical Analysis, 2022, 189(11): 113410.
[60] LI SY.Study on the Quality Evaluation Method of Radix et Rhizoma Pinelliae and the Concoction Process of Radix et Rhizoma Pinelliae[D]. Nanjing: Nanjing University of Traditional Chinese Medicine(南京中医药大学), 2022.
[61] HU C, PAN J, XU Y, et al.Residual Levels and Health Risks of Organochlorine Pesticides and Heavy Metals in the New Eight Genuine Medicinal Materials in Zhejiang(New Zhebawei)[J]. Environmental Science & Technology(环境科学与技术), 2023, 46(1): 203-209.
[62] ZHOU Q, DONG J, JIANG Y, et al.Determination of Banned Pesticide Residues in Foregut by SPE-LC-MS/MS and SPE-GC-MS/MS and Analysis of Results[J]. Zhejiang Journal of Traditional Chinese Medicine(浙江中医杂志), 2022, 57(12): 924-927.
[63] HUANG P.Study on the Improvement of Quality Standard of Sprain Return Capsule[D]. Nanjing: Nanjing University of Chinese Medicine(南京中医药大学), 2023.
[64] LI Y, WANG Z, LI H, et al.Heavy Metal Residual and Related Elemental Species in Polygonum Cillinerve (Nakai) Ohwl[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2023, 20(11): 1234-1237.