关键词: 急性肺损伤, 急性呼吸窘迫综合征, 吲达帕胺, 过敏反应, 不良反应

Abstract: Objective To call attention to rare complications caused by indapamide so as to provide references for clinical treatment. Methods One case of acute respiratory distress syndrome (ARDS) attributed to indapamide intake was reported. The pathogenesis, clinical manifestations, and treatment of this adverse reaction were analyzed bases on domestic and foreign literature. Results After symptomatic treatments including non-invasive ventilatory support, anti-infection therapy, vasopressor therapy, and hydration therapy, the patient’s oxygenation improved, and the chest CT scan showed favorable progression, leading to discharge. However, the underlying mechanism by which indapamide triggered ARDS had yet to be elucidated, so more research was needed to discern its pathogenesis. Conclusion While hypokalemia, hyponatremia, and electrolyte imbalances are commonly reported adverse reactions of indapamide, it is crucial to be vigilant to the rare but potential risks of ARDS associated with its use.

Key words: Acute Lung Injury, Acute Respiratory Distress Syndrome, Indapamide, Anaphylaxis, Adverse Reaction