基于“因毒为能”思想的有毒中药常山毒效转化知识图谱可视化分析

doi:10.19803/j.1672-8629.20230778

中国药物警戒 ›› 2024, Vol. 21 ›› Issue (1): 25-32.
DOI: 10.19803/j.1672-8629.20230778

• 药品安全风险防控新策略与新方法专栏 • 上一篇下一篇

基于“因毒为能”思想的有毒中药常山毒效转化知识图谱可视化分析

马丽娜^1,2, 胡晓祯³, 郑长辉³, 孙颖^4,5, 赵旭^4#, 曹俊岭^1,3,*, 肖小河⁴

¹北京中医药大学东方医院药学部,北京 100078;
²中国中医科学院中药研究所,北京 100700;
³北京中医药大学中药学院,北京 100029;
⁴中国人民解放军总医院第五医学中心,肝病医学部研究所,北京 100039;
⁵长沙市第三医院药学部,湖南长沙 410000

收稿日期:2023-12-14 出版日期:2024-01-15 发布日期:2024-01-18
通讯作者: ^*曹俊岭,博士,主任药师,中药毒性与安全用药研究。E-mail：Caojunling72@163.com; ^#为并列通信作者。
作者简介:马丽娜,博士,助理研究员,中药药理与毒理学研究。
基金资助:
国家自然科学基金资助项目（82104518、82230118）; 国家中医药管理局项目（ZYYCXTD-C-202005）

Visual analysis of knowledge map of toxic Chinese medicine Changshan toxicity-effect transformation based the thought of “yin du wei neng”

MA Li’na^1,2, HU Xiaozhen³, ZHENG Changhui³, SUN Ying^4,5, ZHAO Xu^4#, CAO Junling^1,*, XIAO Xiaohe⁴

¹Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China;
²Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Post-Doctoral Scientific Research Center, Beijing 100700, China;
³School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing 100029, China;
⁴Department of Hepatology, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China;
⁵Department of Pharmacy, The Third Hospital of Changsha, Hunan Changsha 410000, China

Received:2023-12-14 Online:2024-01-15 Published:2024-01-18

1. 2024年1期-基于“因毒为能”思想的有毒中药常山毒效转化知识图谱可视化分析_附加材料.zip(18228KB)

摘要/Abstract

摘要： 目的基于“因毒为能”思想,分析常山抗疟活性成分常山碱及其衍生物的知识图谱,为其毒效转化提供理论依据。方法对中国知网与Web of Science数据库1993年1月1日至2023年10月18日核心集检索,导出相关中英文文献,使用CiteSpace、VOSviewer、Excel软件对中英文文献的发文量、作者、发文机构、国家、被引频次、关键词等进行分析。结果共纳入文献235篇,其中中文137篇,英文98篇。常山碱及常山酮相关文献的年发文量呈现稳步增长趋势,共有18个国家对常山碱及常山酮进行了相关研究,其中研究最多的国家是中国,其次是以色列、美国、日本。中文发文量最多的机构为中国农业科学院兰州畜牧与兽药研究所兽用药物创制重点实验室（11篇）,英文发文量最多的机构为Volcani Institute of Agricultural Research（17篇）。被引频次前10次的中英文文献研究方向为常山碱及常山酮的药理活性、合成等。结论常山碱及其衍生物的研究呈现上升趋势,中英文关键词共现、聚类显示常山碱及常山酮药理活性、毒性、结构修饰是目前的研究热点。对常山碱及其衍生物的抗疟机制、致吐机制及配伍减毒机制的深入研究是未来的重点研究趋势。

关键词: 常山碱, 常山酮, 药理活性, 毒性, 结构修饰, 文献计量, CiteSpace, VOSviewer

Abstract: Objective Based on the idea of “yin du wei neng”, the knowledge map of Dichroa alkali and its derivatives were analyzed to provide theoretical basis for its toxicity-effect transformation.. Methods The relevant literature was retrieved from the core set of CNKICNKI database and Web of Science database from 1 January 1993 to 18 October 2023, and CiteSpace, VOSviewer and Excel software were used to analyze the publication volume, author, publishing agency, country, citation frequency and keywords of Chinese and English literature. Results A total of 235 articles were included, including 137 Chinese and 98 English articles. A total of 18 countries have conducted relevant studies on Ausomine and Authanone, among which the most studied country is China, followed by Israel, the United States and Japan. The institution with the largest number of articles in Chinese is the Key Laboratory of Veterinary Drug Creation of Lanzhou Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences, with 11 articles, and the institution with the largest number of English articles is Volcani Institute of Agricultural Research with 17 articles. The top 10 cited Chinese and English literature mainly focuses on the pharmacological activity and synthesis of alcamine and acanthone. Conclusion The research on alcamine and its derivatives shows an upward trend, and the co-occurrence and clustering of Chinese and English keywords show that the pharmacological activity, toxicity and structural modification of alcamine and astillone are the current research hotspots. The in-depth study of Aytamine and its derived antimalarial mechanism, emetogenic mechanism and compatibility attenuation mechanism is the key research trend in the future.

Key words: febrifugine, halofuginone, pharmacological activity, toxicity, structural modification, bibliometrics, CiteSpace, VOSviewer

中图分类号:

R954
R994.11

马丽娜, 胡晓祯, 郑长辉, 孙颖, 赵旭, 曹俊岭, 肖小河. 基于“因毒为能”思想的有毒中药常山毒效转化知识图谱可视化分析[J]. 中国药物警戒, 2024, 21(1): 25-32.

MA Li’na, HU Xiaozhen, ZHENG Changhui, SUN Ying, ZHAO Xu, CAO Junling, XIAO Xiaohe. Visual analysis of knowledge map of toxic Chinese medicine Changshan toxicity-effect transformation based the thought of “yin du wei neng”[J]. Chinese Journal of Pharmacovigilance, 2024, 21(1): 25-32.

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基于“因毒为能”思想的有毒中药常山毒效转化知识图谱可视化分析

Visual analysis of knowledge map of toxic Chinese medicine Changshan toxicity-effect transformation based the thought of “yin du wei neng”

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