中国药物警戒 ›› 2024, Vol. 21 ›› Issue (1): 59-64.
DOI: 10.19803/j.1672-8629.20230695
• 呼吸道病毒性疾病与中医药防治机制研究专栏 • 上一篇 下一篇
李舒冉1, 郭姗姗1, 冀祖恩2,3, 张薇2,3#, 崔晓兰1,*
收稿日期:
2023-11-03
出版日期:
2024-01-15
发布日期:
2024-01-18
通讯作者:
*崔晓兰,女,博士,研究员,中药防治感染性疾病机制研究。E-mail:cuixiaolan2812@126.com; #为共同通信作者。
作者简介:
李舒冉,女,博士,助理研究员,中药防治感染性疾病机制与神经药理及新药研发。
基金资助:
LI Shuran1, GUO Shanshan1, JI Zuen2,3, ZHANG Wei2,3#, CUI Xiaolan1,*
Received:
2023-11-03
Online:
2024-01-15
Published:
2024-01-18
摘要: 目的 对新型冠状病毒(SARS-CoV-2)与认知功能障碍的关系及新冠后遗症中认知功能障碍的发生机制进行综述。方法 检索中国知网和PubMed数据库,收集2020年1月1日至2023年10月30日中医、西医关于SARS-CoV-2感染后认知功能障碍的相关报道。结果 SARS-CoV-2感染后可能会出现认知功能障碍,这可能与SARS-CoV-2病毒具有神经侵袭性、嗜神经性、神经毒力有关,或与感染后介导的过度炎症反应、血清素水平及病毒转移等因素有关;并发现部分中药单体具有改善SARS-CoV-2感染后认知功能障碍的作用。结论 SARS-CoV-2感染后可能会出现短时间或长期的认知功能障碍,其具体机制有待临床和基础研究的进一步验证,中药在改善此症状中具有较好的研究潜力。
中图分类号:
李舒冉, 郭姗姗, 冀祖恩, 张薇, 崔晓兰. 新型冠状病毒感染后认知功能障碍的研究现状[J]. 中国药物警戒, 2024, 21(1): 59-64.
LI Shuran, GUO Shanshan, JI Zuen, ZHANG Wei, CUI Xiaolan. Research status of cognitive dysfunction after SARS-CoV-2 infection[J]. Chinese Journal of Pharmacovigilance, 2024, 21(1): 59-64.
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