|
Acute toxicity of anti-gastric cancer active ingredients of Ferula ferulaeoides
YANG Minghan, QIAO Meiling, LUO Jiaoyang, YANG Meihua, SHENG Ping
2023, 20(8):
880-884.
DOI: 10.19803/j.1672-8629.20230136
Objective To study the acute toxicity and safety of anti-gastric cancer active ingredients of Ferula ferulaeoides so as to provide reference for the research and development of anti-gastric cancer drugs and clinical medications. Methods The mixed suspension of anti-gastric cancer active ingredients of Ferula ferulaeoides was administered intragastrically to mice at the maximum dose. The mice were weighed before and 14 days after administration. The health and death of mice were observed for 14 consecutive days. On the 14th day after administration, serum was collected, and the white blood cell count (WBC), red blood cell count (RBC), hemoglobin concentration (HGB), platelet count (PLT) and lymphocyte percentage (LYM) of mice were determined. The indexes of the liver, spleen and kidney were calculated by dissecting mice. The pathological sections of the liver, spleen, kidney and stomach were prepared to observe the pathological injury to the organs. Results The maximum dosage of anti-gastric cancer active ingredients of Ferula ferulaeoides for mice was 5.00 g·kg-1. During administration, the mice in the group of anti-gastric cancer active ingredients of Ferula ferulaeoides appeared listless, tired, with erection and dark blood color of hair and sticky feces. Compared with blank control group, there was no significant difference in body weight before and 14 d after administration (P > 0.05), or in white blood cell count (WBC), red blood cell count (RBC), hemoglobin concentration (HGB), platelet count (PLT) and lymphocyte percentage (LYM) (P > 0.05), or in the indexes of the liver, spleen and kidney (P > 0.05). Histopathological results showed no significant pathological changes in the liver, spleen, kidney or stomach. Conclusion The anti-gastric cancer active ingredients of Ferula ferulaeoides cause no serious toxic reactions within 14 days, without any significant effect on the weight and diet of mice or on the liver, spleen, kidney and stomach of mice, but irritative reactions may occur within 2h of administration. This may be caused by nerve irritation or gastrointestinal irritation of the anti-gastric cancer active ingredients of Ferula ferulaeoides.
References |
Related Articles |
Metrics
|