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Analysis of 1110 Cases of Drug-induced Liver Injury in 79 Hospitals
JIA Wang-ping, GUO Dai-hong, TIAN Xiao-yan, KOU Wei, WANG Xiao-yu, ZHAO Su-yu, HU Peng-zhou
2017, 14(8):
481-485.
Objective To investigate the condition and characteristics of drug-induced liver injury(DILI), and provide reliable basis for theprevention and treatment of DILI. Methods The cases of DLLI were collected from database of PLA ADR Monitoring Center from 2008 to 2016 and then patients' information, suspicious drugs, laboratory indexes and major manifestations, occurring time of DILI and administration route, treatment and outcomes were analyzed retrospectively. Results Among 1 110 DILI cases, the ratio of males and females was 1.51:1. Significant differences of age existed between males and females (χ2=25.136, P=0.01). The three predominant drug classifications were anti-infective agents, nervous system drugs, cardiovascular system drugs orderly. The predominant drugs were atorvastatin, rifampicin, moxifloxacin and levofloxacin orderly. Significant difference of outcomes existed between patients taking liver-protecting drugs and patients not taking liver-protecting drugs (χ2=25.136,P<0.001).Conclusion Clinical medical staffs should learn more about drugs and use them reasonably, drug withdrawal and other symptomatic treatments should be given in time for patients with DILI.
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