Abstract: Objective To study the clinical effects of risperidone and modified electroconvulsive therapy for refractory schizophrenia. Methods 104 patients with refractory schizophrenia in our hospital from October 2012 to October 2013 were selected, randomly divided into the observation group and the control group with 52 cases for each one. Modified electroconvulsive therapy was used in the observation group. Risperidone was used in the control group. Results Observation showed that TESS score and efficiency during treatment had no significant difference (P>0.05). After treatment, PANSS scores of two groups were better than before (P <0.05). But PANSS scores of observation group in 2 week and 4 week were better than control group (P <0.05). The cost of treatment was also better than control group (P <0.05). Conclusion These results show that risperidone and modified electroconvulsive therapy for refractory schizophrenia have the equal efficacy and safety, but the speed of onset and treatment cost of modified electroconvulsive therapy have advantages.

Key words: refractory schizophrenia, risperidone, modified electroconvulsive therapy