Abstract: ObjectiveTo investigate the long-term toxicity reaction in rats given Zhujie Yiweian Capsule(ZYC) continuously. MethodsSD rats were divided into 4 groups randomly(n=20), namely normal control, ZYC high, medium and low dose groups(150, 85 and 20 g·kg-1, respectively). ZYC was orally administered for 26 weeks. The body weight and food intake were observed and calculated during the administration. The hematology and blood biochemistry analysis were carried out, and organ histopathological changes were also observed under the microscope at the end of the administration and 4 weeks after the administration, respectively. ResultsThe appearance and behavior and body weight in rats of ZYC groups showed no significant difference compared to the normal control group. In hematology analysis, ZYC increased platelet and white blood cell count, decreased red blood cell count and remarkably prolonged the prothrombin time, which should be associated with the antithrombotic effect of ZYC. In biochemistry analysis, ZYC significantly inhibited AST, increased TP and BUN contents. In addition, ZYC elevated the liver and spleen coefficients. In histopathological observation, ZYC showed no apparent influence in organs of rats. No delayed toxicity reaction was showed 4 weeks after the administration. ConclusionZYC(20 to 150 g·kg-1) shows no obvious toxicity in rats for long-term administration.

Key words: Zhujie yiweian capsule, rats, long-term toxicity