Abstract: Objective To exert licensed pharmacists' role in protection of the public rational drug use. Methods The data of rational drug use importance and domestic licensed pharmacist career development were collected and analyzed, initiatives were proposed to play the role of licensed pharmacist in China and protect the public reasonably safe and effective use of drugs. Results There is a big gap between China and foreign countries in licensed pharmacist qualification, practice management and continuing education, licensed pharmacists may play a greater role in the protection of public rational drug use, through perfecting the system, improving qualily, providing pharmacy services and other initiatives. Conclusion licensed pharmacists should constantly improve the quality and deliver high-quality pharmacy services for patients. Licensed pharmacists are the protectors of the public rational drug use.