Chinese Journal of Pharmacovigilance ›› 2015, Vol. 12 ›› Issue (8): 462-463.

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Study on Acute Toxicity of Arctigenin Injection in SD Rats

LIU Song-jiang1, LIU Song-yan2   

  1. 1. Linyi Yishui Central Hospital, Shandong Linyi 276400, China;
    2. Center for New Drug Safety Evaluation of Lunan Pharmaceutical, Shandong Linyi 273400, China
  • Received:2015-09-02 Revised:2015-09-02 Online:2015-08-08 Published:2015-09-02

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Abstract: Objective To study the acute toxicity of arctigenin injection in rats by Up-and-Down Procedure(UDP). Methods The UDP test includes intravenous injection group and subcutaneous injection group, according to the AOT425 StatPgm administration. 40 healthy SD rats were divided into two groups, 20 each. Results LD50 of intravenous injection group is 8.9 mg·kg-1, the 95% confidence interval is 6.6~17.5 mg·kg-1. LD50 of subcutaneous injection group is 227.3 mg·kg-1, the 95% confidence interval is 166.3~348 mg·kg-1. Conclusion In this study, arctigenin intravenous injection has greater toxicity, subcutaneous injection is relatively safe.

Key words: arctigenin, Up-and-Down Procedure, acute toxicity

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