Abstract: Objective To statistically analyze utilization of fluoroquinolone antibiotic drugs and resistance rate of bacteria in a hospital from 2011 to 2013, and study the relationship between them, so as to reduce bacterial resistance and provide references for clinical rational use of antibacterial drugs. Methods Retrospective investigation method was used to statistically analyze the pathogenic bacteria culture Results, antibacterial cumulative frequency and Results of drug resistance test. SPSS 17.0 software was used to analyze Pearson correlation coefficient of the resistant rates of bacteria and antibacterial consumption. Results The frequency of fluoroquinolone antibacterial drug use decreased from 29 237.90 DDDs in 2009 to 11 296.65 DDDs in 2013, cumulatively declined by 61.36%. In addition to the fluoroquinolone use and Staphylococcus haemolyticus (r=-0.68) and Enterococcus faecium (r=-0.86) resistance rate were negatively correlated, positive correlation has been found with the common bacteria resistance rate, there is a significant positive correlation with E. coli (r=0.95), Enterobacter cloacae (r=0.88) and Enterococcus faecalis (R=0.95). Conclusion The frequency of fluoroquinolone antibacterial drug use showed a declining trend in a hospital. In addition to Staphylococcus haemolyticus and Enterococcus faecium, drug use of fluoroquinolones and common pathogenic bacteria was positively correlated, the frequency of fluoroquinolone antibacterial drug use may be a main factor to increase certain bacteria resistance rate.

Key words: bacterial resistance, fluoroquinolone, Defined Daily Dose