Abstract: Objective To observe the clinical effection of modified Xiaoyaosan in treating chronic hepatitis B with Syndrome of liver stagnation and spleen deficiency. Methods 60 patients of chronic hepatitis B with syndrome of liver stagnation and spleen deficiency were chosen for clinical observation, and randomly divided into experimental group and control group. After12 weeks' treatment, to observe the patients' improvements such as clinical symptoms, biochemical indicators, immunological targets, pathogen indicators and so on. Results After the treatment of 12 weeks, the total efficiency of experimental group is 83.33%, and 66.67% of the control group. Experimental group was significantly better than the control group(P <0.05). The experimental group is superior to the control group in the improvement in Syndrome of TCM, biochemical, immunological indicators and HBV-DNA negative conversion rate, and there are statistical differences between the two groups(P <0.05). Conclusion Modified xiaoyaosan can effectively improve Syndrome of TCM, regulate cell immunity, restore liver function and enhance anti-viral response rate.

Key words: Modified xiaoyaosan, Syndrome of liver stagnation and spleen deficiency, Chronic Hepatitis B