Abstract: Objective To understand the clinical characteristics, treatment and its outcome of African malaria. MethodsClinical data of 135 malaria patients are analyzed. ResultsAmong the clinical manifestations, 135 cases(accounting for 100%) got fever, in which there are 31 patients with anemia(accounting for 22.96%), 27 patients with splenomegaly(accounting for 20.00%), 21 patients with diarrhea(accounting for 15.56%), and 19 patients with vomiting(accounting for 14.07%). All above are the most common clinical manifestations. Then there are various symptoms as cough(17 patients, accounting for 12.59%), chill(7 patients, accounting for 5.19%) and so on. 135 patients all accepted antimalarial treatment with artesunate drugs. These 135 patients were cured and no one died. ConclusionMost African malaria is malignant with a high morbility, and clinical manifestations are complicated and not typical. So early diagnosis and prompt treatment are the key to improve the disease prognosis. Artesunate drugs are safe, effective and the first choice to malaria treatment.

Key words: malaria, cure, artesunate drugs, malignant malaria