Abstract: Objective Explore the clinical effect of antibiotics to treat 60 elderly patients with chronic renal insufficiency and bacterial infection, and influence to the renal function. MethodsChoosing 60 elderly patients with chronic renal failure and 60 elderly patients with normal renal function, all patients were suffered from lower respiratory tract infection, who were treated by Ceftazidime in our hospital from May 2008 to October 2011. Observe the difference of clinical effect and renal function change before and after treatment. ResultsThe average treatment time of observation group and control group were(10.15±3.23) d and (7.32±2.18) d (P<0.05); There were no statistical means of overall treatment effect(P>0.05), but difference of cure rate between two groups was significant(P<0.05); Besides, the difference of SCr, BUN, and CCr before and after treatment is significant(P <0.05). ConclusionUsing Antibiotics to treat bacterial infection of elderly patient with chronic renal insufficiency is harder than treating with elderly patients normal renal function. More attention need to be paid to them, and once presents renal insufficiency, the drug should be immediately discontinued, treat them with hemodialysis when necessary.

Key words: antibiotics, chronic renal insufficiency, elderly, ceftazidime