Chinese Journal of Pharmacovigilance ›› 2026, Vol. 23 ›› Issue (3): 273-279.
DOI: 10.19803/j.1672-8629.20250423

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Aromatic Substances of Perillae Folium Volatile Oil Based on GC-MS and E-Nose Technology

ZHANG Meiqi1, QIAN Qi1,2,3, XIE Zeyang1, NIU Liying1,2,3#, WANG Xinguo1,2,3,*   

  1. 1School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang Hebei 050091, China;
    2Hebei Traditional Chinese Medicine Formula Granule Engineering & Technology Innovate Center, Shijiazhuang Hebei 050091, China;
    3Quality Evaluation & Standardization Hebei Province Engineering Research Center of Traditional Chinese Medicine, Shijiazhuang Hebei 050091, China
  • Received:2025-06-30 Online:2026-03-15 Published:2026-03-17

Abstract: Objective To study the differences in the composition and aroma of an volatile oil from Perillae Folium grown in different regions so as to find out about the aromatic substances of such oil. Methods Gas chromatography-mass spectrometry (GC-MS) and E-nose technology were used to conduct multivariate statistical analysis of the composition and aroma of a volatile oil from Perillae Folium grown in different areas in order to find the differences in composition and aroma. The aromatic substances of this volatile oil were screened out via correlation analysis. Results A total of 48 volatile components were identified by GC-MS, represented by terpenes and their oxides, alcohols and ketones. The E-nose could distinguish samples of volatile oils from Perillae Folium grown in Guangxi, Hebei and Anhui provinces. Based on Pearson correlation analysis, 19 aromatic substances were identified, including linalool, perillaldehyde, caryo-phyllene oxide, and egomaketone. Conclusion GC-MS and E-nose combined with multivariate statistical analysis can effectively distinguish the volatile oil of Perillae Folium from different regions, reveal the differences in composition and aroma, and determine the aromatic substances. This study is expected to provide a reference for quality evaluation of Perillae Folium.

Key words: Perillae Folium, Volatile Oil, Aromatic Substances, Terpenes, Alcohols, Ketones, E-Nose, GC-MS

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