One Case of Toxic Epidermal Necrolysis Caused by Moxifloxacin Hydrochloride and Sodium Chloride Injection

doi:10.19803/j.1672-8629.20241028

Abstract

Abstract: Objective To analyze one case of toxic epidermal necrolysis (TEN) caused by moxifloxacin hydrochloride and sodium chloride injection in order to provide a reference for rational drug use in clinic. Methods One case of TEN caused by moxifloxacin hydrochloride and sodium chloride injection in an adult patient with lung squamous cell carcinoma was analyzed, the sensitizing drug was identified, and the causes and risk factors were analyzed. Results According to clinical symptoms and medication of the patient, moxifloxacin hydrochloride and sodium chloride injection was identified as the sensitizing drug of TEN via the Algorithm of Drug Causality for Epidermal Necrolysis (ALDEN) standards. Effective treatment was offered and the patient was gradually improved. The pathogenesis of TEN linked to moxifloxacin hydrochloride and sodium chloride injection remained unclear, and risk factors were hypoproteinemia and hypersensitivity reactions to β-lactam antibiotics. Conclusion Clinicians who prescribe moxifloxacin hydrochloride and sodium chloride injection should be alert to the risk of TEN, monitor adverse reactions, especially among patients with a history of allergy, and ensure safety in clinical practice.

Key words: Moxifloxacin Hydrochloride and Sodium Chloride, Injection, Toxic Epidermal Necrolysis, Hypoproteinemia, Lung Squamous Cell Carcinoma, ALDEN, Adverse Drug Reactions

CLC Number:

SI Fuguo, CUI Jia, CHENG Jun, ZHU Yulin, DAI Biao. One Case of Toxic Epidermal Necrolysis Caused by Moxifloxacin Hydrochloride and Sodium Chloride Injection[J]. Chinese Journal of Pharmacovigilance, 2025, 22(11): 1307-1309.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20241028

https://zgywjj.magtechjournal.com/EN/Y2025/V22/I11/1307

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