One Case of Hematological Abnormalities Caused by Lipoic Acid Injection

doi:10.19803/j.1672-8629.20240658

Abstract

Abstract: Objective To investigate the adverse drug reactions relating to lipoic acid induced hematological abnormalities so as to provide a reference for its safe clinical applications. Methods One case of hematological abnormalities after injections of lipoic acid was analyzed, and related literature was retrieved to help find the proper medication. Results Fourteen days after lipoic acid injection, blood routine examination results of the patient showed decreased levels of white blood cells, red blood cells and hemoglobin. The lipoic acid injection was discontinued and replaced by leucogen tablets. Three days after treatment, levels of the three indicators mentioned above improved. Conclusion Clinicians should be alert to the potential adverse effects of lipoic acid on the hematological system, particularly in cases with longer disease durations and multiple medications, whose risk of adverse drug reactions may increase.

Key words: Lipoic Acid, Injection, Hematological Abnormalities, White Blood Cells, Red Blood Cells, Hemoglobin, Adverse Drug Reactions

CLC Number:

R972
R994.11

LIU Ying, GUO Hongye, YANG Yiheng, JIN Rui. One Case of Hematological Abnormalities Caused by Lipoic Acid Injection[J]. Chinese Journal of Pharmacovigilance, 2025, 22(4): 456-459.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20240658

https://zgywjj.magtechjournal.com/EN/Y2025/V22/I4/456

References

[1] GHIBU S, LAUZIER B, DELEMASURE S, et al.Antioxidant Properties of Alpha-Lipoic Acid: Effects on Red Blood Membrane Permeability and Adaptation of Isolated Rat Heart to Reversible Ischemia[J]. Molecular and Cellular Biochemistry, 2009, 320(1-2): 141-148.
[2] Branch Group of Neurological Complication, Chinese Diabetes Society. Expert Consensus on Diagnosis and Treatment of Diabetic Neuropathy(2021 edition)[J]. Chinese Journal of Diabetes Mellitus(中华糖尿病杂志), 2021, 13(6): 540.
[3] ZHANG XL, XU PQ, LI WL, et al.Effects of Α-Lipoic Acid on Serum Uric Acid and Renal Function in Patients of Type 2 Diabetes Mellitus[J]. Chinese Journal of Hospital Pharmacy(中国医院药学杂志), 2024, 44(12): 1452-1456.
[4] MEI CH, WANG FF, LIN X, et al.Efficacy of Lipoic Acid Combined with Ankle Pump Exercise in the Treatment of Diabetic Foot and the Regulatory Role of TGF-β1/Smad3 Signaling Pathway[J]. Modern Practical Medicine(现代实用医学), 2024, 36(4): 522-525.
[5] YANG XT, CHEN HH, LIU GF, et al.Retrospective Analysis of 29 Cases of Adverse Reactions to Lipoic Acid Injection in a Hospital[J]. Drug Evaluation(药品评价), 2021, 18(22): 1402.
[6] LEI ZZ, HUA GD, ZHU BK, et al.A Case of Anaphylactic Shock Induced by Lipoic Acid Injection[J]. Chinese Journal of Clinical Pharmacy(中国临床药学杂志), 2023, 32(12): 931-933.
[7] ZHANG K, TANG ZH, TIAN YC.A Case of Insulin Autoimmune Syndrome Induced by Lipoic Acid[J]. Journal of Clinical Rational Drug Use(临床合理用药杂志), 2021, 14(5): 151-152.
[8] SUN ZL, CHENG XL, ZHENG GM.Lipoic Acid Induced Insulin Autoimmune Syndrome[J]. Chinese Journal of Diabetes(中国糖尿病杂志), 2024, 32(10): 778-781.
[9] LIANG L,YU LP,ZHANG D, et al.Insulin Autoimmune Syndrome Induced by Lipoic Acid: Analysis of Literature in China and Abroad[J]. Drugs & Clinic(现代药物与临床), 2022, 37(4): 882-887.
[10] MENDES PRF, FÉLIX DOS, DA SILVA PCD, et al. Effect of Alpha Lipoic Acid on the Blood Cell Count and Iron Kinetics in Hypertensive Patients[J].Nutricion Hospitalaria, 2014, 31(2): 883-889.
[11] HUERTAAE, PRIETO-HONTORIA PL, SAINZ N, et al. Supplementation with α-Lipoic Acid Alone or in Combination with Eicosapentaenoic Acid Modulates the Inflammatory Status of Healthy Overweight or Obese Women Consuming an Energy-Restricted Diet[J]. Journal of Nutrition, 2015, 146(4): 889S-896S.
[12] ŠABANOVIĆ M, JAŠIĆ M, ODOBAŠIĆ A, et al. Alpha-Lipoic Acid Reduces Symptoms and Inflammation Biomarkers in Patients with Chronic Haemorrhoidal Illness[J]. International Journal for Vitamin and Nutrition Research, 2019, 88(5-6): 281-290.
[13] NUNES DLD, LUZ WCFC, JUSTA IF,et al.α-Lipoic Acid as Adjunctive Treatment for Schizophrenia: a Randomized Double-Blind Study[J]. Journal of Clinical Psychopharmacology, 2023, 43(1): 39-45.
[14] ZAHABI SE, ABDOLLAHZAD H, NACHVAK MS, et al.Effects of Alpha Lipoic Acid on Iron Overload, Lipid Profile and Oxidative Stress Indices in β-Thalassemia Major Patients: a Cross-Over Randomised Controlled Clinical Trial[J]. International Journal of Clinical Practice, 2021, 75(6): e14062-e14062.
[15] FERGUSON I, FOGG C,BAUGHAN P.Spironolactone Induced Agranulocytosis[J]. Medical Journal of Australia, 1993, 159(11-12): 837.
[16] HSIAO SH, LIN YJ, HSU MY, et al.Spironolactone-Induced Agranulocytosis: a Case Report[J]. Kaohsiung Journal of Medical Sciences, 2003, 19(11): 574-577.
[17] LIU X, ZHAO X, FENG XY, et al.Function of Naranjo's Assessment Scale in the Evaluation of Adverse Reactions of Salvianolic Acid Polyphenols for Injection[J]. China Medicine and Pharmacy(中国医药科学), 2021, 11(9): 58-62.
[18] LIU J, SONG Q, HUANG Y, et al.R-Lipoic Acid Overdosing Affects Platelet Life Span via ROS Mediated Autophagy[J]. Platelets, 2017, 29(7): 695-701.
[19] GANJI FM, ABDOLMOHAMMADI N, NIKBINA M, et al.Prevalence of Anemia in Patients with Diabetes Mellitus: a Systematic Review and Meta-Analysis[J]. Biomedical and Environmental Sciences: BES, 2024, 37(1): 107-196.
[20] RUPASINGHE S, JAYASINGHE KI.Prevalence and Associated Factors of Anaemia in Patients with Type 2 Diabetes Mellitus: a Cross-Sectional Study in a Tertiary Care Medical Unit, Sri Lanka[J]. BMC Endocrine Disorders, 2024, 24(1): 156.
[21] DWAIRI AA, SHBOUL AO, U'DATT AFGD, et al. Effect of Poor Glycemic Control on the Prevalence and Determinants of Anemia and Chronic Kidney Disease among Type 2 Diabetes Mellitus Patients in Jordan: An Observational Cross-sectional Study[J]. PLoS One, 2024, 19(11): e0313627.
[22] OLUM R, BONGOMIN F, KAGGWA MM, et al.Anemia in Diabetes Mellitus in Africa: a Systematic Review and Meta-Analysis[J]. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2021, 15(5): 102260.
[23] DU YJ,ZHANG Y,YANG HX.Pharmaceutical Care of Patients with Leukopenia Induced by Moxifloxacin[J]. Herald of Medicine(医药导报), 2018, 37(S1): 111-113.
[24] WANG J.Be Vigilant of Drug-Induced Leukopenia[J]. Capital Food Medicine(首都食品与医药), 2000(11): 51.
[25] PANG QQ.Factors Potentially Associated with Chemotherapy-Induced Anemia in 102 Patients with Postoperative Breast Cancer[D]. Nanning: Guangxi Medical University, 2017.
[26] XIONG L,NING F,SHI YB.Research Progress on the Role of Iron Overload in the Pathogenesis of Diabetes[J]. Journal of Medical Research(医学研究杂志), 2019, 48(7): 164-167.
[27] HU YL, FENG ZA, YUAN JY.Advances in the Application of Common Leukocyte-Stimulating Drugs in Cancer Treatment[J]. China Pharmacy(中国药房), 2015, 26(9): 1294-1296.
[28] YANG X.Clinical Effect of Interval Iron Supplementation in the Treatment of Iron Deficiency Anemia[J]. Chinese Journal of Modern Drug Application(中国现代药物应用), 2021, 15(5): 130-132.
[29] SU Z.Analysis of the Clinical Effects of Iron Sucrose Injection Therapy in Patients with Iron Deficiency Anemia[J]. Heilongjiang Medicine and Pharmacy(黑龙江医药科学), 2023, 46(6): 128-130.
[30] CHEN ZW, FAN H, DONG B.Analysis of Curative Effect of Ferrous Succinate on Iron Deficiency Anemia[J]. Systems Medicine(系统医学), 2023, 8(18): 100-102.