Abstract: Objective To investigate the relationship of oxidative damage mechanism in hepatic toxicity caused by different components from Rhizoma Menispermi in mice. Methods Mice were administrated with water extracted and alcohol extracted components for 7 days. The level of MDA、SOD、NO、NOS、GSH、GSH-Px in serum and hepatic tissue were detected. Results The water extracted and alcohol extracted components can cause the activity of MDA in serum and liver increased, the level of SOD corresponding induced, however the level of NO and NOS increased. In addition the activity of GSH and GSH-Px reduced. All the changes were aggravated in accordance with the dosages. Conclusion The continuous administration of water extracted and alcohol extracted components from Rhizoma Menispermi to mice can induce obvious hepato-toxicity injury; the approach of hepatic damage is related with the peroxidative damage mechanism.

Key words: Rhizoma Menispermi, water extracted and alcohol extracted components, hepatotoxicity, oxidative damage mechanism