Abstract: Objective To observe the treatment effects and mechanisms of Kangbingdu oral liquid against influenza A (H1N1) virus infection. Methods ICR mice were infected by influenza A (H1N1) virus FM1 strain and PR8 strain. After treatment, the lung index, virus load and the level of MDA、TNF-α and IFN-γ in serum were measured; MDCK cells were infected by influenza A (H1N1) virus, after treatment, the activation of neuraminidase(NA) was measured. Results Compared with model group, Kangbingdu oral liquid significantly reduced the lung index of mice, significantly reduced the virus load, inhibited the level of TNF-α and increased the level of IFN-γ in vivo; Kangbingdu oral liquid significantly inhibited the activation of NA in vitro (P<0.05 or P<0.01). Conclusion Kangbingdu oral liquid has good therapeutic effects on viral pneumonia caused by influenza A (H1N1) virus through the inhibition of inflammatory response and virus copy.

Key words: Kangbingdu oral liquid, influenza A, virus load, TNF-α, IFN-γ, neuraminidase