Abstract: Objective To investigate the adverse effects of bisoprolol induced the general rules and characteristics. Methods We searched the "China Journal Full-text Database"and"Chinese Scientific and Technial Periodicals Database" in 1994 and 2009 due to adverse drug reactions bisoprolol, and statistical analysis. Results Bisoprolol caused a total of 13 cases of adverse reactions, more men than women. Adverse reactions due to a maximum of sinoatrial, atrioventricular block in 5 patients(38.46%), followed by secondary amenorrhea in 2 cases(15.38%), urinary system diseases in 2 cases(18.36%), respiratory disorder in 2 cases(18.36 %), neurological problems and 1(7.70%). Conclusion The clinical application should strengthen monitoring of bisoprolol in order to reduce the incidence of adverse reactions.

Key words: Bisoprolol, adverse reactions, literature analysis