Abstract: Objective To explore the effects of extended pharmaceutical care in and out of hospital on blood glucose control, medication compliance and adverse reactions in patients with 2 type diabetes mellitus. Methods 142 patients with type 2 DM in our hospital from January 2016 to January 2017 were enrolled and randomly divided into study group and control group, 30 cases in each group. The control group received routine pharmaceutical care; the study group additionally received extended pharmaceutical care in and out of hospital as medication education, telephone follow-up, etc. The levels of glycosylated hemoglobin, fasting blood glucose, rate of blood glucose compliance, medication compliance and rate of adverse reactions were compared between the two groups of patients before and after intervention. Results There was no statistical difference in the levels of glycosylated hemoglobin, fasting blood glucose, rate of blood glucose compliance and medication compliance between the two groups before intervention (P >0.05). After intervention, the levels of glycosylated hemoglobin and fasting blood glucose of patients in the two groups were significantly decreased (P<0.05); the rate of blood glucose compliance was significantly increased (P <0.05); those in the study group were significantly better than the control group (P <0.05); the blood glucose control effect in patients ＜ 60 years old were significantly better than patients ≥ 60 years old (P <0.05). After intervention, the rate of good medication compliance was significantly increased in the two groups (P <0.05); that in the study group was significantly better than the control group (P <0.05); the improvement of medication compliance in patients ＜ 60 years old was significantly better than patients ≥ 60 years old (P <0.05). After intervention, the rate of adverse reactions in the study group was significantly lower than the control group (P <0.05). Conclusion The extended pharmaceutical care in and out of hospital could contribute to blood glucose control, improve the medication compliance, decrease the rate of adverse reactions, especially for patients ＜ 60 years old.

Key words: 2 type diabetes mellitus, extended pharmaceutical care, blood glucose control, medication compliance, adverse reaction