Abstract: Objective To observe the effect of rosuvastatin on serum leptin, inflammatory factors, blood lipid and renal function in patients with early diabetic nephropathy. Methods 80 cases of diabetic nephropathy (DN) patients were selected and randomly divided into control group(40 cases) and observation group(40 cases). Two groups were treated with conventional treatment. The patients in the observation group were given 10 mg rosuvastatin every day on the basis of the conventional treatment. Two groups of patients were treated for 12 weeks. The changes of serum leptin, inflammatory factor, blood lipid and renal function were compared between the two groups before and after treatment. Results After treatment, the serum leptin, C reactive protein (hs-CRP), tumor necrosis factor-ɑ(TNF-ɑ), interleukin 6 (IL-6), triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), blood urea nitrogen (BUN), serum creatinine (Scr) and 24 h urinary albumin excretion rate (UAER) level of the observation group were significantly lower than those of the control group and the same group before treatment (P<0.05). The high density lipoprotein (HDL) and glomerular filtration rate (GFR) of the observation group were significantly higher than those of the control group and the same group before treatment (P<0.05). Conclusion Besides decreasing the levels of serum leptin and inflammatory factors, rosuvastatin can significantly reduce the blood lipid level, and improve renal function, which have a certain clinical value for the diagnosis and treatment of DN.

Key words: rosuvastatin, diabetic nephropathy, leptin, inflammatory factor, blood lipid, renal function