Abstract: Objective To investigate the clinical efficacy and safety of Fufanghuashengyi granules in treatment of thrombocytopenia induced by chemotherapy. Methods 80 cases of cancer patients were collected from March 2013 to March 2016 in our hospital, according to the grade of thrombocytopenia induced by chemotherapy, I and II degree patients were divided into control group (40 cases, given conventional therapy) and treatment group (40 cases, given Fufanghuashengyi granules) using random digital method, compared the clinical efficacy and safety differences of the two groups. Results Compared with the control group, the PLT, Hb count and the minimum value of PLT of treatment group both significantly increased, the time of PLT back to 50 or 100×109·L^-1 significantly shortened, with statistical significance (P<0.05). Logistic multiple regression model showed that Fufanghuashengyi granules had significantly antagonistic effect to vomiting, fever, fatigue and edema (P<0.05). Conclusion Fufanghuashengyi granules in treatment of I and II degree thrombocytopenia induced by chemotherapy has good clinical effect, and safety is relatively high, it is worth to be popularized and applied.

Key words: Fufanghuashengyi granule, chemotherapy, thrombocytopenia