Literature Analysis of 193 Cases of Adverse Reactions of Xanthii Fructus

Abstract

Abstract: Objective To explore the clinical toxicity characteristics and risk factor, in order to offer literature basis for clinical safety medication. Methods The adverse reactions of Xanthii Fructus on literatures between January 1st, 1953 April 1st, 2016 were summarized, the toxicity characteristics and risk factors for clinical use were analyzed. Results Oral and external use of Xanthii Fructus can lead to adverse reactions. Oral use of Xanthii Fructus caused multiple organ damage, the main damages are digestive damage and liver damage. External use of Xanthii Fructus caused skin lesions, the main damage was contact dermatitis. The main risk factors of adverse reactions/events of Xanthii Fructus were misuse in children, inappropriate drug processing, overdosage, using out of the direction of doctor, using folk prescription and patients, physique. Conclusion Toxicity of Xanthii Fructus should be paid attention in the clinical use, so as to control the risk factors and prevent the happening of adverse drug reactions.

Key words: Xanthii Fructus, adverse reaction, literature analysis

CLC Number:

R994.11

YANG Xue, XIA Dong-sheng, GAO Jian-chao, TIAN Chun-hua, LI Lan, ZHANG Bing. Literature Analysis of 193 Cases of Adverse Reactions of Xanthii Fructus[J]. Chinese Journal of Pharmacovigilance, 2016, 13(11): 691-696.

References

[1] 国家药典委员会.中国药典一部[M]. 北京:中国医药科技出版社, 2015:162.
[2] 佚名.誤食蒼耳子中毒三例报告[J]. 中医杂志, 1960, 6:28.
[3] 王元汉. 苍耳子中毒症状复杂易于误诊—两例误诊例分析[J].实用内科杂志, 1981, 1(1):53.
[4] 李聚善. 苍耳子中毒6例报告[J]. 人民军医, 1981, 10:31-32.
[5] 郭汉林. 急性鲜苍耳子中毒12例报告[J]. 临床内科杂志, 1989,6(2):29.
[6] 李华恩. 小儿苍耳子中毒[J]. 中国农村医学, 1990, 2:24.
[7] 胡志华. 中药苍耳子引起中毒性肝炎1例报告[J]. 江苏医药,1991, 8:426.
[8] 朱晓东. 苍耳子中毒致急性左心衰竭一例[J]. 临床心血管病杂志, 1993, 9(4):223.
[9] 黄道同,姜永利,王志武.苍耳子致肝肾功能衰竭一例[J].临床误诊误治, 1994, 7(3):127.
[10] 赵秀珍,赵振霄,徐岩. 急性苍耳子中毒致急性肾功能衰竭1例[J]. 康复与疗养杂志, 1996, 11(1):48.
[11] 吴秀珍. 苍耳子慢性中毒导致心肌损害、肝功能损害14例[J].医学理论与实践, 1996, 9(7):312.
[12] 张权儒.苍耳子中毒昏迷39天抢救成功1例[J].中国中医急症,1996, 5(4):179.
[13] 辛兰英. 苍耳子梗喉误诊2例的护理观察[J]. 齐鲁护理杂志,1996, 2(5):64.
[14] 冯杰,王清兰.苍耳子外用引起按触性皮炎17例[J]. 中国皮肤性病学杂志, 1996, 10(5):318.
[15] 孙逊,黑淑娥.腹膜透析抢救苍耳子中毒致多器官损害1例[J].山东医药, 1997, 37(2):63.
[16] 杨新建,梁颖. 外用苍耳子致接触性皮炎1例[J]. 中草药,1998,9:620.
[17] 梁晓燕,朱会友,王建丽.小剂量苍耳子中毒1例[J].实用中医药杂志, 1998, 14(10):45-46.
[18] 高继宁,钱雅玉,李宜放,等. 血液透析抢救儿童服苍耳子致急性肝肾功能衰竭一例[J]. 山西医药杂志, 1999, 28(6):467.
[19] 张玮,刘佃全,李玉胜,等. 外用苍耳子引起接触性皮炎1例[J].中国中药杂志, 2001, 26(5):68.
[20] 牛玉英,孙建国,张鑫. 大剂量苍耳子中毒1例[J]. 现代中西医结合杂志, 2002, 11(19):1950.
[21] 高冬. 外用苍耳子致接触性皮炎1例[J]. 临床皮肤科杂志,2004, 33(9):570.
[22] 赵胜乾,吴敏.苍耳子中毒致急性肾功能衰竭及肝损伤1例[J].实用诊断与治疗杂志, 2004, 18(6):514.
[23] 周加权.以多器官损害为表现的苍耳子中毒1例报告[J].中国社区医师, 2005, 21(5):47.
[24] 林睦明. 苍耳子致血小板减少性紫癜[J]. 临床误诊误治,2006,19(1):80.
[25] 廖丽锦.中药苍耳子致不良反应1例报告[J].新中医, 2006,38(7):91.
[26] 魏婧婧. 苍耳子致炎性肌病1例报告[J]. 实用中医药杂志,2008,24(8):542.
[27] 徐宁,黄留业,李绥军.大剂量苍耳子中毒致急性肝功损害1例[J].滨州医学院学报,2010,33(3):191.
[28] 陈积民,李季涛,张立敬,等.苍耳子中毒1例[J].沈阳部队医药, 2012, 25(1):8.
[29] 汪玫,瞿金涛,戴兵,等. 服用苍耳子致急性肝肾功能损伤一例并文献复习[J]. 中国全科医学, 2013, 16(2):218-220.
[30] 马斌智. 超常规剂量苍耳子中毒致室速一例报告[J]. 青海医药杂志, 2013, 43(1):32.
[31] 李杰,房庆华,吕晓红. 1例外敷苍耳子致接触性皮炎的护理[J].中外医疗, 2013, 32(12):156-158.
[32] 杨晓红. 苍耳子中毒致脑功能不可逆损伤1例[J]. 中医儿科杂志, 2014, 10(3):62-63.
[33] 张茏,陈世汉,张志茂,等.幼儿声门区苍耳子异物1例[J]. 临床耳鼻咽喉头颈外科杂志, 2014, 28(18):1440-1441.
[34] 马锐,李文英,刘大锁,等. 误食苍耳子中毒1例[J]. 药物流行病学杂志, 2000, 9(3):123.
[35] 张磊,刘映红,彭佑铭,等. 苍耳子引起急性肝肾功能损害一例报告[J].中国医师杂志, 2010, 12(12):1615-1619.
[36] 贾文俊.苍耳子中毒1例[J]. 现代养生, 2013, (10):113-113.
[37] 马天龙.苍耳子中毒2例报告[J]. 中国保健营养（中旬刊）,2013,(10):495-495.
[38] 郭春芳,陈光,陈晴燕,等. 外用苍耳子致接触性皮炎1例[J].中国实用乡村医生杂志, 2012, 19(11):57.
[39] 刘健,刘莉,樊建红,等.外用苍耳子致接触性皮炎一例[J].中华皮肤科杂志, 2008, 41(7):468.
[40] 张虹,张亚静,康哓英. 外用苍耳子致接触性皮炎27例[J]. 中国皮肤性病学杂志, 1996, 10(3):183.
[41] 韩丽君,杨英梅. 苍耳子中毒致死一例[J]. 中原医刊, 1984, 4:25-26.
[42] 刘克勤.苍耳子中毒致死一例[J].临床医学, 1989, 9(5):227.
[43] 阎芳华. 过量服用苍耳子中毒致死一例[J]. 山西医药杂志,2007, 36(3):212.
[44] 阚卫军,贺盟. 苍耳子中毒死亡1例[J]. 法医学杂志, 2012, 28(1):63-64.
[45] 杨慧明. 苍耳子中毒致死3例报告(摘要)[J]. 新医学,1976, 1:30.
[46] 韩阳.外用苍耳子致接触性皮炎1例[J].中国实用乡村医生杂志,2009, 16(6):52-52.
[47] 李永春. 儿童苍耳子中毒致肝衰竭1例分析[J]. 中国现代医生,2015, 53(29):122-124.
[48] 崔斌,苗勇,陈维海,等. 超常剂量苍耳子中毒1例急救处置体会[J]. 创伤与急危重病医学, 2015, 3(6):376-377.
[49] 贾春伶,李锦.苍耳子及其制剂致肝损害34例临床分析[J].人民军医, 2016, 59(4):401-402.
[50] Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, et al. Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside[J].Nature, 2003, 426(6962): 39-44.
[51] Obatomi D K, Bach P H. Biochemistry and toxicology of the diterpenoid glycoside atractyloside[J]. Food and chemical toxicology, 1998,36(4): 335-346.
[52] 汪洋.中药苍耳子的毒性物质基础及中毒机制研究[D].第二军医大学, 2010:16-28.