Abstract: Objective To analyze the cases of low blood sugar reactions caused by glibenclamide and identify the relevant factors, provide a reference for the clinical use of drugs. Methods 742 cases of glibenclamide -induced low blood sugar reactions were statistically analyzed. Results Male to Female ratio was 1.1:1,88.0% of the cases are the elderly, 39.6% of them had non -standard situation of drug use, 14.6% of them used single drug, 43.9% of them had the combined use of drugs. Clinical types of the cases were mainly hypoglycemic coma(62.7% ), 93.5% of them were cured ,48 cases showed adverse outcome (death in 41 cases). Conclusion Glibenclamide can cause relatively severe low blood sugar reactions, and even lead to death. When use, the age, usage, dosage and other factors must be carefully considered, so as to medicate rationally and then reduce the incidence of hypoglycemia.

Key words: glibenclamide, drug-induced hypoglycemia, rational drug use