Abstract: Objective To compare the acute toxicity of different components in Artemsia argyi on mice. Methods Respectively prepare the water extraction components, volatile oil, alcohol extraction components and all components to compare the acute toxicity of different components in Artemsia argyi on mice in accordance with classical acute toxicity test Methods. Results The LD₅₀ and 95% confidence limit of water extraction components and volatile oil in Artemsia argyi are respectively 80.2 g·kg^-1·d^-1(77.4~83.4 g·kg^-1·d^-1)and 1.67 mL·kg^-1·d^-1 (1.55~1.80 mL·kg^-1·d^-1); The MTD of alcohol extraction components and the MLD of all components are respectively 75.6 g·kg^-1·d^-1 and 24.0 g·kg^-1·d^-1,which are espectively equal to 588.0 times and 186.7 times of 70kg adult’s daily dried medicinal herb expenses. The main acute toxicity symptoms and signs are negligent respectively equal to 588.0 times and 186.7 times of 70kg adult’s daily dried medicinal herb expenses. The main acute toxicity symptoms and signs are negligent action, nausea, convulsions, tetraplegia, prone fixed. Conclusion The acute toxicity of different components in Artemsia argyi on mice is: volatile oil >water extraction components> alcohol extraction components >all components, but the toxic substances,process of toxicity in vivo,toxicity characteristics,and toxicity mechanism are all not yet entirely clear,and they are all to be further studied.

Key words: Folium Artemsia Argyi, different components, mice, acute toxicity