Abstract: Objective To investigate the situation of adverse drug reaction(ADR) of nervous system(NS), offer references for rational application in clinical ptactice. Methods 1 672 reports collected by Guizhou Center for ADR monitoring from Janury,1st 2006 to December, 31th 2008 were analyzed using retrospective study method. Results The reports of ADR of NS accounted for 10.45% in all reports. The ratio of male to famal was 1 1.04. 19~59 years old account for 73.10%. The NS lesion included sympathetic and parasympathetic system(1 206 cases), central and periphersl nervous system .The clinical manifestations of the former mainly were palpitation, vomiting and diarrhea, the latte's mainly were dizziness, headache and local numbness. These ADR cases were induced by 22 kinds of drugs and most of them caused by cephalosporins. Intravenous injection is the main way for administration. Conclusion We should pay attention to drug-induced damage to the NS, timely detect, diagnose, treatment and prevent ADR of NS.

Key words: nervous system, adverse drug reaction(ADR), report, analysis