Abstract: Objective To investigate the clinical characteristics of conjunctival congestion caused by hemocoagulase agkistrodon for injection in patients with perioperative bleeding so as to provide a reference for safe clinical medication. Methods Two cases of conjunctival congestion that occurred after the postoperative use of hemocoagulase agkistrodon for injection for hemostasis were analyzed. Related literature was reviewed. Results Two pediatric patients experienced conjunctival congestion immediately after using hemocoagulase agkistrodon for injection. There was a significant temporal correlation. According to the Naranjo's Adverse Drug Reaction Probability Scale, the causality was assessed as possible. After quick symptomatic treatment, the patients recovered. Conclusion The risk of anaphylactic shock caused by hemagglutinin is unpredictable, which deserves the attention of medical staffs. Before prescribing the drug in high-risk populations, clinicians should take safety into consideration and take precautions.

Key words: Haemocoagulase Agkistrodon, Injection, Children, Postoperative, Perioperative Bleeding, Conjunctival Congestion, Adverse Drug Reaction