One case of rhabdomyolysis caused by piperacillin sodium and tazobactam sodium for injection

doi:10.19803/j.1672-8629.20250918

Abstract

Abstract: Objective To explore the risk of rhabdomyolysis induced by piperacillin sodium and tazobactam sodium for injection and provide a reference for clinical safe medications. Methods One case of rhabdomyolysis caused by piperacillin sodium and tazobactam sodium for injection used to combat infection in a patient with infection complicated with diabetic ketoacidosis (DKA) was analyzed. The clinical manifestations, possible mechanisms, and prevention of adverse drug reactions (ADRs) were explored based on literature. Results Rhabdomyolysis was believed to be linked to piperacillin tazobactam. After discontinuation of the drug, the levels of MYO and CK decreased significantly, and muscle pain disappeared. Conclusion Clinicians should be vigilant about the potential risk of rhabdomyolysis induced by piperacillin sodium and tazobactam sodium for injection. Early detection and prompt interventions are critical to mitigating severe neurological complications.

Key words: Piperacillin Sodium and Tazobactam Sodium for Injection, Rhabdomyolysis, Adverse Drug Reaction, Diabetic Ketoacidosis (DKA)

CLC Number:

R978
R994.11

Xing Luyu, Xing Yinghong, Fan Wen, Zhang Shuyi. One case of rhabdomyolysis caused by piperacillin sodium and tazobactam sodium for injection[J]. Chinese Journal of Pharmacovigilance, 2026, 23(9): 1062-1064.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20250918

https://zgywjj.magtechjournal.com/EN/Y2026/V23/I9/1062

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