Abstract: Objective To explore the pharmacological effects, clinical applications and association of trimetazidine with Parkinson’s syndrome in order to provide a reference for safe and rational use of the drug. Methods Literature about experiments on and clinical use of trimetazidine in the past five years was retrieved to find out more about the pharmacological effects and clinical applications of trimetazidine. The possible mechanisms through which trimetazidine was involved in Parkinson’s syndrome were explored. Results The latest research found that trimetazidine could deliver anti-apoptosis, antioxidant, anti-pyroptosis and anti-inflammation effects while regulating autophagy and metabolism, suggesting that it could be used in the treatment of acute ST-segment elevation myocardial infarction, chronic heart failure, viral myocarditis and severe pneumonia. Parkinson’s syndrome was linked to autophagy dysfunction, necroptosis pathway, mitochondrial dysfunction, and epigenetic modifications. Conclusion The pharmacological effects of trimetazidine have been summarized. This drug combats a range of diseases while inducing Parkinson’s syndrome through multi-targets and multi-pathways. This study is expected to provide evidence for subsequent studies on the related mechanisms and disease-inducing factors.

Key words: Trimetazidine, Apoptosis, Autophagy, Oxidation, Pharmacology, Parkinson’s Syndrome