Abstract: Objective To analyze the clinical characteristics and treatments of scrotal inflammation with local necrosis induced by dapagliflozin so as to provide a reference for safe clinical practice. Methods One case of scrotal inflammation with local necrosis induced by dapagliflozin was analyzed and the possible mechanism, clinical characteristics, and treatment regimens were investigated based on literature. Results After 4 months of taking dapagliflozin, the patient developed epididymo-orchitis. Related literature and time correlations of medication suggested that this symptom might have been caused by dapagliflozin. The patient was discharged after right testicular epididymis resection under intraspinal anesthesia. Conclusion When dapagliflozin is used in clinic, clinicians need to alert to adverse reactions in the urogenital system, which may lead to surgery or even threaten life if left untreated.

Key words: Dapagliflozin, Scrotal Inflammation, Local Necrosis, Adverse Drug Reactions