One Case of Acute Hepatic Injury Caused by Pregabalin Capsules

doi:10.19803/j.1672-8629.20250614

Abstract

Abstract: Objective To explore the characteristics of acute hepatic injury caused by pregabalin capsules in order to provide a reference for safe clinical use and management of adverse reactions. Methods One case of acute hepatic injury caused by oral pregabalin capsules was analyzed. The correlations between hepatic injury and pregabalin were investigated, and the pathogenesis of acute hepatic injury caused by pregabalin was analyzed based on related literature before ways of prevention and treatment were recommended. Results The patient experienced hepatic injury after using pregabalin for 12 days. Clinical pharmacists traced the patient's medications, referred to the drug instructions and reviewed related literature before they concluded that hepatic injury was related to pregabalin. Therefore, they recommended that the drug be discontinued. The patient's liver function returned close to normal following hepatoprotective treatment ten days after discontinuation. Conclusion Clinicians are to be alert to the risk of such adverse reactions as hepatic injury caused by pregabalin. In case of hepatic injury, related drugs should be discontinued promptly and symptomatic treatment should be given to ensure safe medication.

Key words: Pregabalin, Acute Hepatic Injury, Drug-Induced Liver Injury, Adverse Drug Reactions, Rational Drug Use

CLC Number:

R971
R994.11

WANG Aming, WEI Xiao, WU Hui, ZHANG Linlin, YANG Li. One Case of Acute Hepatic Injury Caused by Pregabalin Capsules[J]. Chinese Journal of Pharmacovigilance, 2026, 23(5): 578-580.

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https://zgywjj.magtechjournal.com/EN/Y2026/V23/I5/578

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