One Case of Joint Pain and Muscle Weakness Caused by Dupilumab Injection

doi:10.19803/j.1672-8629.20250622

Abstract

Abstract: Objective To investigate such adverse reactions as joint pain and muscle weakness induced by dupilumab, and to explore the possible mechanisms in order to provide a reference for safe use of the drug. Methods One case of a patient with severe asthma who developed joint pain and muscle weakness after using dupilumab was analyzed. The correlation of these adverse events with dupilumab was studied. Furthermore, related literature was reviewed and summarized. Results After the drug instructions and literature were reviewed and the time of administration was analyzed, other combination drugs were excluded. The correlation between dupilumab and the adverse reactions of joint pain and muscle weakness was determined as “probable”. These symptoms gradually improved after drug discontinuation and supportive treatment. Conclusion Clinicians should be alert to the adverse reactions of joint pain and muscle weakness associated with dupilumab. When treatment with this drug is restarted, the risks and benefits should be weighed and monitored.

Key words: Dupilumab Injection, Bronchial Asthma, Joint Pain, Muscle Weakness, Adverse Drug Reaction

CLC Number:

ZHANG Qin, ZHENG Xiaoyuan. One Case of Joint Pain and Muscle Weakness Caused by Dupilumab Injection[J]. Chinese Journal of Pharmacovigilance, 2026, 23(5): 581-584.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20250622

https://zgywjj.magtechjournal.com/EN/Y2026/V23/I5/581

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