Chinese Journal of Pharmacovigilance ›› 2026, Vol. 23 ›› Issue (3): 323-327.
DOI: 10.19803/j.1672-8629.20250827

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Adverse Reactions and Risk Factors of Voriconazole for Injection

LI Yujie1,2, MA Jiantong1, ZHANG Wenjing2, GUO Hao2,3,*   

  1. 1School of Pharmacy, Baotou Medical College, Baotou Inner Mongolia 014040, China;
    2Department of Pharmacy, Inner Mongolia Autonomous Region People’s Hospital, Hohhot Inner Mongolia 010017, China;
    3Inner Mongolia Autonomous Region Essential Drug Monitoring and Clinical Comprehensive Evaluation Center, Hohhot Inner Mongolia 010017, China
  • Received:2025-11-20 Online:2026-03-15 Published:2026-03-17

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Abstract: Objective To analyze the adverse reactions and potential risk factors of voriconazole for injection so as to provide a reference for proper clinical applications. Methods The medical records of patients treated with voriconazole for injection in Inner Mongolia Autonomous Region People’s Hospital in 2020-2024 were collected. The patients with adverse reactions related to voriconazole for injection were assigned to the study group while those without served as the control group at a ratio of 1∶4 based on propensity score matching. Univariate and multivariate logistic regression analyses were conducted to identify risk factors for adverse reactions related to voriconazole for injection. Results A total of 665 patients treated with voriconazole for injection were included, 44 of whom had 68 related adverse reactions, so the overall incidence was 6.62%. The adverse reactions primarily involved the nervous system (35.29%) and blood system (33.82%). Multivariate logistic regression analysis indicated that diabetes [P=0.004, OR=3.250, 95%CI(1.448-7.297)], previous surgery [P=0.038, OR=2.167, 95%CI(1.042-4.507)], history of allergy [P=0.033, OR=2.729, 95%CI(1.083-6.873)], history of blood transfusion [P=0.040, OR=2.241, 95%CI(1.038-4.835)] and duration of medication (ranging from 14 d or less to 21 d) [P=0.011, OR=8.365, 95%CI(1.626-43.041)] might be independent risk factors for adverse reactions related to voriconazole for injection. Conclusion In the clinical application of voriconazole for injection, the patients’ diabetes, previous surgery, history of allergy, history of blood transfusion and medication duration should be taken into consideration while adverse reactions involving the nervous system and blood system deserve more attention. Pharmacovigilance should be implemented when necessary to detect and deal with adverse drug reactions immediately and ensure the safety of medication.

Key words: Voriconazole, Adverse Drug Reactions, Diabetes, Previous Surgery, History of Allergy, History of Blood Transfusion, Medication Duration, Risk Factors

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