Abstract: Objective To establish the evaluation standard for voriconazole injection based on weighted TOPSIS, and provide a reasonable basis for clinical application. Methods The reasonable application evaluation system of voriconazole injection was established based on weighted TOPSIS with reference to the dispensatory and application guide of voriconzole, and 100 voriconazole injection utilizing cases that happened in the first half of 2017 in our hospital were evaluated. Results Among the 100 patients, there were 25 cases whose relative approach degree were larger than 80％(accounting for 25％), 37 cases whose relative approach degree were between 60％~80％(accounting for 37％), and 38 cases whose relative approach degree were below 60％(accounting for 38％). Conclusion The reasonable application evaluation system of voriconazole injection based on weighted TOPSIS Methods can be used to evaluate the rationality of drug use and promote more rational evaluation behavior. The results showed that irrational administrations of voriconzole for injection are fairly common problems in our hospital, which means regulation should be strengthened.

Key words: weighted TOPSIS method, voriconzole injection, drug use evaluation