Literature Research and Risk Analysis of Nitrous Oxide Abuse

Abstract

Abstract: Objective To review the research status of nitrous oxide abuse, and provide reference for preventing the abuse of nitrous oxide and reducing its serious harm. Methods The domestic and foreign literature databases were retrieved, and the history of development and usage of nitrous oxide, pharmacological mechanism and clinical application, the harm of abuse and the situation at home and abroad were reviewed and summarized. Results The abuse of nitrous oxide could cause diseases relating to vitamin B12 deficiency, lead to mild paralysis and even threaten life. The abuse rate in Europe and United States was 15%~40% and 4%~8%, respectively, while surveillance data of abuse in China has not been retrieved. Conclusion The abuse situation of young people everywhere was very serious, and the supervision measures in China were not perfect. To avoid the abuse of nitrous oxide, the relevant departments should strengthen the management and monitoring of nitrous oxide.

Key words: nitrous oxide, abuse, literature research, risk analysis

CLC Number:

R994.11

LIU Zhi-jun, YUAN Xing-dong, ZHANG Wei, ZHOU Juan, XU Yu-ming. Literature Research and Risk Analysis of Nitrous Oxide Abuse[J]. Chinese Journal of Pharmacovigilance, 2018, 15(2): 116-120.

References

[1] 王丽, 范其江, 董明睿, 等. 滥用笑气中毒致神经系统损害一例[J]. 中国现代神经疾病杂志, 2016, 16(8): 533-535.
[2] Kaar S J, Ferris J, Waldron J, et al. Up: The rise of nitrous oxide abuse. An international survey of contemporary nitrous oxide use[J]. Journal of Psychopharmacology, 2016, 30(4): 395-401.
[3] Beckman N J, Zacny J P, Walker D J. Within-subject comparison of the subjective and psychomotor effects of a gaseous anesthetic and two volatile anesthetics in healthy volunteers[J]. Drug and alcohol dependence, 2006, 81(1): 89-95.
[4] Nagele P, Duma A, Kopec M, et al. Nitrous oxide for treatment-resistant major depression: a proof-of-concept trial[J]. Biological psychiatry, 2015, 78(1): 10-18.
[5] Binkerd E F, Kolari O E. The history and use of nitrate and nitrite in the curing of meat[J]. Food and cosmetics toxicology, 1975, 13(6): 655-661.
[6] Butzkueven H, King J O. Nitrous oxide myelopathy in an abuser of whipped cream bulbs[J]. Journal of clinical neuroscience, 2000, 7(1): 73-75.
[7] Maze M, Fujinaga M. Pharmacology of nitrous oxide[J]. Best Practice & Research Clinical Anaesthesiology, 2001, 15(3): 339-348.
[8] Sanders R D, Weimann J, Maze M. Biologic Effects of Nitrous OxideA Mechanistic and Toxicologic Review[J]. The Journal of the American Society of Anesthesiologists, 2008, 109(4): 707-722.
[9] Gruss M, Bushell T J, Bright D P, et al. Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane[J]. Molecular pharmacology, 2004, 65(2): 443-452.
[10] Ohashi Y, Guo T, Orii R, et al. Brain stem opioidergic and GABAergic neurons mediate the antinociceptive effect of nitrous oxide in Fischer rats[J]. The Journal of the American Society of Anes-thesiologists, 2003, 99(4): 947-954.
[11] Banks R G S, Henderson R J, Pratt J M. Reactions of gases in solution. Part III. Some reactions of nitrous oxide with transition-metal complexes[J]. Journal of the Chemical Society A: Inorganic, Physical, Theoretical, 1968: 25(1), 2886-2889.
[12] Frasca V, Riazzi B S, Matthews R G. In vitro inactivation of methionine synthase by nitrous oxide[J]. Journal of Biological Chemistry, 1986, 261(34): 15823-15826.
[13] Van Amsterdam J, Nabben T, Van den Brink W. Recreational nitrous oxide use: Prevalence and risks[J]. Regulatory toxicology and pharm-acology, 2015, 73(3): 790-796.
[14] Nagele P, Duma A, Kopec M, et al. Nitrous oxide for treatment-resistant major depression: a proof-of-concept trial[J]. Biological psychiatry, 2015, 78(1): 10-18.
[15] Leslie K, Myles P S, Chan M T V, et al. Nitrous oxide and long-term morbidity and mortality in the ENIGMA trial[J]. Anesthesia & Analgesia, 2011, 112(2): 387-393.
[16] Imberger G, Orr A, Thorlund K, et al. Does anaesthesia with nitrous oxide affect mortality or cardiovascular morbidity? A systematic review with meta-analysis and trial sequential analysis[J]. British journal of anaesthesia, 2014, 112(3): 410-426.
[17] Va sman A I. Working conditions in the operating room and their effect on the health of anesthetists[J].Eksperimental'naia khirurgiia i anesteziologiia, 1967, 12(3): 44.
[18] McGregor D G, Baden J M, Bannister C, et al. Waste Anesthetic Gases: Information for the Management in Anesthetizing Areas and the Postanesthesia Care Unit (PACU)[J]. Park Ridge, IL: American Society of Anesthesiologists, 1999, 63(1): 22.
[19] O'Donovan M R, Hammond T G. Is nitrous oxide a genotoxic carcinogen[J]. Mutagenesis, 2015, 30(4): 459-462.
[20] Richardson K J, Shelton K L. N-Methyl-d-Aspartate Receptor Channel Blocker-Like Discriminative Stimulus Effects of Nitrous Oxide Gas[J]. Journal of Pharmacology and Experimental Therapeutics, 2015, 352(1): 156-165.
[21] Walker D J, Zacny J P. Analysis of the reinforcing and subjective effects of different doses of nitrous oxide using a free-choice procedure[J]. Drug and alcohol dependence, 2002, 66(1): 93-103.
[22] Zacny J P, Lichtor J L, Coalson D W, et al. Time course of effects of brief inhalations of nitrous oxide in normal volunteers[J]. Addiction, 1994, 89(7): 831-839.
[23] Jakovljevic M, Vidmar G, Mekjavic I B. Psychomotor function during mild narcosis induced by subanesthetic level of nitrous oxide: Individual susceptibility beyond gender effect[J]. Undersea & Hyperbaric Medicine, 2012, 39(6): 1067.
[24] Chiang T T, Hung C T, Wang W M, et al. Recreational nitrous oxide abuse-induced vitamin B12 deficiency in a patient presenting with hyperpigmentation of the skin[J]. Case reports in dermatology, 2013, 5(2): 186-191.
[25] Chen H J, Huang C S. Nitrous Oxide-induced Subacute Combined Degeneration Presenting with Dystonia and Pseudoathetosis: A Case Report[J]. Acta Neurologica Taiwanica, 2016, 25(2): 50-55.
[26] Mancke F, Kaklauskait G, Kollmer J, et al. Psychiatric comorbidities in a young man with subacute myelopathy induced by abusive nitrous oxide consumption: a case report[J]. Substance abuse and rehabilitation, 2016, 7(1): 155.
[27] Hirvioja J, Joutsa J, Wahlsten P, et al. Recurrent paraparesis and death of a patient with 'whippet'abuse[J]. Oxford medical case reports, 2016, 2016(3): 41-43.
[28] Ghodse A H, Corkery J, Ahmed K, et al. Trends in UK deaths associated with abuse of volatile substances, 1971-2009[J]. International Centre for Drug Policy , 2012, 1(24): 22-26.
[29] Cheng H M, Park J H, Hernstadt D. Subacute combined degeneration of the spinal cord following recreational nitrous oxide use[J]. BMJ case reports, 2013, 2013(8): 1.
[30] Garakani A, Welch A K, Jaffe R J, et al. Psychosis and low cyanocobalamin in a patient abusing nitrous oxide and cannabis[J]. Psychosomatics, 2014, 55(6): 715-719.
[31] Winstock A R. The global drug survey 2014. findings[J]. Global Drug Survey, 2014.
[32] ACMD. Advisory Council on the Misuse of Drugs (ACMD). Advice on nitrous oxide [EB/OL](2015-03-04)[2017-07-15]. https://www.gov.uk/government/publications/acmd-advice-on-nitrous-oxide-abuse.
[33] Nabben T, Benschop A, Korf D J. Antenne 2013: trends in alcohol, tabak en drugs bij jonge Amsterdammers[J]. Rozenberg Publishers, 2014, 97(11): 1, 3-17.
[34] Goossens F X, Frijns T, Hasselt N E, et al. Het grote uitgaansonderzoek 2013. Uitgaanspatronen, middelengebruik en risicogedrag onder uitgaande jongeren en jongvolwassenen[J]. Trimbos-instituut, Utrecht, 2013.
[35] Substance Abuse and Mental Health Services Administration. National Survey on Drug Use and Health [EB/OL]. (2015)[2017-07-15]. https://www.icpsr.umich.edu/icpsrweb/SAMHDA/ssvd/studies/35509/datasets/0001/variables/NITOXID?q=NITOXID&series=Nati-onal+Survey+on+Drug+Use+and+Health+%28NSDU H%29+Series&paging.start Row=26.
[36] GDS. Global Drug Survey 2015 findings. What did we learn from GDS2015? An overview of our key findings [EB/OL]. [2017-07-16] https://www.globaldrugsurvey.com/the-global-drug-survey-2015-findings/.
[37] 王丽. 滥用笑气青少年身心很受伤[N]. 健康报,2017-07-07(4).