Pharmaceutical Care of a Patient with Hydroxychloroquine Induced Long QT Syndrome

Abstract

Abstract: Objective To analyze pharmaceutical care on one case of long QT syndrome(LQTS) induced by hydroxychloroquine (HCQ) sulfate tablets, so as to provide reference to the clinical safe medication. Methods By collecting the correlative papers and analyzing clinical drug use, we analyzed the correlation between the prescriptions and LQTS. Results HCQ has a significant correlation with LQTS, it induced prolongation of the QT interval and torsades de pointes(TdP). Conclusion HCQ is a drug with conditional TdP risk. We should pay attention to clinical medication and measures to prevent and deal with similar ADR.

Key words: hydroxychloroquine(HCQ), adverse drug reaction(ADR), long QT syndrome

CLC Number:

R994.11

ZHAO Rui, CUI Xiangli, LIU Lihong. Pharmaceutical Care of a Patient with Hydroxychloroquine Induced Long QT Syndrome[J]. Chinese Journal of Pharmacovigilance, 2018, 15(11): 690-692.

[1]	HUO Yanfei, TIAN Yuejie, XU Lili, XIE Yanjun, CHANG Hong, SUN Chunxiao, LI Xia. 535 reports of new and serious adverse drug reactions caused by preparations of lappaconitine hydrobromide [J]. Chinese Journal of Pharmacovigilance, 2023, 20(8): 921-926.
[2]	ZHUANG Hongyan, ZANG Yannan, LIU Shanshan, NIU Mengxi, FANG Meng, YIN Dongqing, GUO Wei. Analysis of neuropsychiatric adverse reactions caused by zolpidem [J]. Chinese Journal of Pharmacovigilance, 2022, 19(8): 889-892.
[3]	LYU Tianyi, KUANG Li, CHEN Mingying. Analysis of 1073 Cases of Clinical Use of Reduning Injection by Pareto Chart and Fishbone Diagram [J]. Chinese Journal of Pharmacovigilance, 2020, 17(10): 745-748.
[4]	XU Shungui. 105 Cases of Adverse Drug Reactions Indcued by Ibuprofen in Our Hosptial [J]. Chinese Journal of Pharmacovigilance, 2019, 16(3): 164-167.
[5]	LIU Chen, CHU Yanqi, YAN Suying, JIN Chao, LIU Tong, XING Liqiu, ZHANG Xiao. Analysis of 93 Reports of Adverse Drug Reactions Induced by Edaravone Injection [J]. Chinese Journal of Pharmacovigilance, 2019, 16(3): 174-178.
[6]	ZHAO Cui-hong, TAO Yi-xiu, WANG Sheng-hai, ZHAO Qiang, MENG Qing-yong, ZHANG Han-xiang, QING Ming-ying, MA Wen-xia, MI Man. Study on Related Factors of Postoperative Nausea and Vomiting and Clinical Intervention in Patients with Intraspinal Anesthesia [J]. Chinese Journal of Pharmacovigilance, 2018, 15(4): 201-204.
[7]	WANG Lin, LI Shuang, LI Hua-bin, JU Yong-jing. Analysis of Adverse Drug Reactions about 141 Cases of Dextran 40 and Amino Acids Injection [J]. Chinese Journal of Pharmacovigilance, 2018, 15(1): 45-48.
[8]	JIA Wang-ping, GUO Dai-hong, TIAN Xiao-yan, KOU Wei, WANG Xiao-yu, ZHAO Su-yu, HU Peng-zhou. Analysis of 1110 Cases of Drug-induced Liver Injury in 79 Hospitals [J]. Chinese Journal of Pharmacovigilance, 2017, 14(8): 481-485.
[9]	LIN Zhi-qiang, WANG Da-xuan, ZHANG Bao-yan. Application of Intensive Hospital Monitoring in Adverse Drug Reaction Supervision of Inpatients Admitted to Respiratory Department [J]. Chinese Journal of Pharmacovigilance, 2017, 14(4): 249-253.
[10]	FAN Yan, TANG Ren, JING Chun-mei ,LI Xin-ling. Discussion on the Key Points of Article Describing Adverse Drug Reaction Case in Pharmaceutical Journal [J]. Chinese Journal of Pharmacovigilance, 2017, 14(2): 99-101.
[11]	ZHUANG Hong-yan, LIU Shan-shan ,GUO Wei, MA Xin, HAO Hong-bing ,ZHANG Yi ,NIU Song. Analysis of 121 Cases of Adverse Drug Reactions in Elderly Patients in Psychiatry [J]. Chinese Journal of Pharmacovigilance, 2017, 14(2): 105-108.
[12]	ZHANG Li-jun,SONG Jiao-jiao. Analysis of 372 Cases of Adverse Drug Reactions Induced by Ornidazole Sodium Chloride Injection [J]. Chinese Journal of Pharmacovigilance, 2017, 14(10): 622-625.
[13]	WU Zhao-zhao, LONG Li-ping, CHEN Xi, CHEN Guang-jian. Analysis of 193 Cases of Adverse Drug Reactions Induced by Zhengqingfengtongning Sustained Release Tablets [J]. Chinese Journal of Pharmacovigilance, 2016, 13(8): 489-491.
[14]	LI Ning, REN Jing-tian. Discussion on How Drug Manufacturers Report Individual Case Adverse Drug Reactions [J]. Chinese Journal of Pharmacovigilance, 2016, 13(2): 80-83.
[15]	XU Li-li, TIAN Yue-jie, XIE Yan-jun, CUI Xiao-kang, ZHAI Shu-yue. Analysis of 160 Cases of Adverse Drug Reaction Characteristics and Risk Factors of Osteomalacia Induced by Adefovir [J]. Chinese Journal of Pharmacovigilance, 2015, 12(8): 487-490.

Pharmaceutical Care of a Patient with Hydroxychloroquine Induced Long QT Syndrome

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics