Abstract: Objective To analyze adverse drug reactions(ADRs) of dextran 40 and amino acids injection(DAAI) reported by safety monitoring system in our hospital and promote clinical rational use of drugs. Methods From January 2010 to June 2017, there are totally 141 cases of ADRs, they were analyzed in respects of the patients' age, gender, department distribution, occurrence time, ADR manifestations and severity, and the number reported in recent years. Results Of the 141 reports, the ration of female was higher than male who experienced ADRs, 58.87% of patients were between 21 and 40 years old and 45.71% of patients come from obstetrical department. The adverse reactions of DAAI mainly appeared in less 30 minutes on the first day. The most common ADRs occurred in skin and its appendants(24.9%) and respiratory system(23.69%). Serious adverse events occurred in 43 patients(30.50%). The number of ADR reports was increased on the first half of 2017. Conclusion With high incidence and high application risk, the DAAI ' ADR must be drawned attention, and DAAI should be properly used to reduce the adverse reactions.

Key words: dextran 40 and amino acids injection, anaphylactic shock, adverse drug reaction(ADR), analysis