Abstract: Objective To understand the cognition on drug safety knowledge and drug use behavior of middle school students in remote minority areas, and to raise the cognition on drug safety knowledge and correct irrational drug use behavior by formulating effective interventions. Methods Cluster stratified random sampling method was adopted to investigate the cognition on drug safety knowledge and drug use behavior, according to the survey to formulate intervention measures, the intervention effect was evaluated. Results Before the intervention, students lacked knowledge of drug safety and reasonable medication. However, the cognition of students’ drug safety knowledge was increased after the intervention, more students chose to go to the hospital to buy drugs and paid more attention to the contents of the drug instruction, students’ self-protection awareness after the occurrence of adverse reactions and the rights consciousness after the purchase of counterfeit drugs were increased. Conclusion The interventions can raise the students’ cognition on drug safety knowledge and correct irrational drug use behavior.

Key words: middle school students, drug safety knowledge, drug use behavior, intervention