Abstract: Objective To investigate the anesthesia effect of dexmedetomidine combined with propofol in gastroscopy. Methods 78 cases of patients were randomly divided into observation group and control group who received intravenous anesthesia painless gastroscopy. The control group received propofol,and the observation group received dexmedetomidine and propofol. Results Within groups, in T1, T2, T3 three time points, HR value of the observation group was significantly lower than the value at T0 (P <0.05), MAP and SpO2 values were significantly lower than T0 in control group (P <0.05). At T1, T2 two time points, MAP and SpO2 of the observation group was significantly higher (P <0.05). At T1, T2, T3 three time points, HR value of the observation group was significantly lower than in the control group (P <0.05). The observation group was significantly lower than the control group in total amount of propofol, anesthesia time, numerical aspects of recovery time and orientation recovery time (P <0.05). The overall incidence of adverse reactions was 15.4% and 35.9% in observation group and the control group, respectively. The observation group was significantly lower (P <0.05). In T1, T2 and T3 depth of anesthesia, the observation group was higher (P <0.05). Conclusion Dexmedetomidine combined with propofol showed a well anesthesia effect, could be used in gastroscopy.

Key words: gastroscopy, anesthesia, dexmedetomidine, propofol