Abstract: Objective To Compare the effect of rivaroxaban and low molecular heparin to prevent deep venous thrombosis in the abdomen after radical resection of tumor. Methods The cases of abdominal tumor resection were randomly divided into test group of 48 cases and control group of 47 cases. The test group started to take rivaroxaban 10 mg orally in 24 hours after operation, once per day for 2 weeks. The control group of patients with low molecular heparin, began to take regular doses of subcutaneous injection of 0.3 mL in 24 hours after the operation, for 10 consecutive days. The indexes of activated partial thromboplastin (APTT), prothrombin time (PT), fibrinogen (Fbg), platelet (Plt) were evaluated before operation and on the 14th day after operation. D-two dimer content of venous blood was measured before operation and on the 1st, 3th, 7th, and 14th day after operation. And drainage volumes 2 days after operation were observed. Results Two cases had DVT in test group patients with the occurrence rate of 4.17%. One case had DVT in control group patients with the occurrence rate of 2.13%, no statistically significant differences was found between the two groups(P ＞0.05). Two groups of patients with APTT, PT, Fbg, Plt, D-two dimer content had no statistically significant differences before and after operation(P ＞0.05). Conclusion Both rivaroxaban and low molecular heparin have satisfying anticoagulation for patients after radical resection of abdominal tumor.

Key words: rivaroxaban, after radical resection of abdominal tumor, deep venous thromborsis