Abstract: ObjectiveTo explore the curative effect of lansoprazole and herbs in treating chronic atrophic gastritis of spleen and stomach dampness-heat syndrome. MethodsNinety-two patients were separated into the treatment group (one group) and the control groups(two groups) randomly, the treatment group took lansoprazole and herbs, the control group 1 took lansoprazole, the control group 2 took herbs. The clinical effects of the three groups were compared. ResultsThe total effective rate of the treatment group was higher than that of the control groups(93.6% vs 63.3% 74.2%, P<0.05), combination therapy can obviously improve the syndromes, eliminate helicobacter pylori infection and improve the changes of gastric mucosa. ConclusionThe clinical effect of lansoprazole combined with herbs in treating atrophic gastritis superior to that of monotherapy, which should strengthen the in-depth study of syndrome, usage, course of treatment of combination therapy, in order to ensure the rationality and effectiveness of the combined use of drugs.

Key words: lansoprazole, herbs, spleen and stomach dampness-heat, chronic atrophic gastritis