Chinese Journal of Pharmacovigilance ›› 2014, Vol. 11 ›› Issue (12): 714-716.

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Study on Serum Pharmacochemistry of Fritillaria Thunbergii Miq. by LC-MS in Rats

MA Yan-yan1, WEN Qing-hui2, TONG Xiao-lin1, 3, FAN Bin1, SUN Jian1, *   

  1. 1Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China; 2Information Center of China Food and Drug Administration, Beijing 100053, China; 3Yunnan University of TCM, Yunnan Kunming 650500, China
  • Received:2014-10-14 Revised:2016-02-03 Online:2014-12-08 Published:2016-03-02

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Abstract: ObjectiveTo study serum pharmacochemistry of Fritillaria thunbergii Miq. after oral administration．MethodsThe constituents absorbed into blood were determined by comparing the mass spectrometry fingerprints of extraction of Fritillaria thunbergii Miq. and herb serum sample. ResultsNine original compounds were detected and six of them absorbed into blood, which were verticine, verticinone, peimisine, isoverticine, ebeiedinone and puqie-

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