Abstract: Objective To research the mechanism based on liver oxidative damage path of the toxical and side effects accompanied with anti-inflammation of water and alcohol extract from . Thus, we try to provide experimental basis of intrahepatic material change for the study of correlation between toxicity and efficacy of Methods First, we made ear swelling model by compound recipe of croton oil and made granuloma model by injecting agar subcutaneously. Second, model mice were intragastricaly treated with different doses of water and alcohol extracts from for 3 and 7 days continually. Then the levels and activities of SOD, MDA, NO, NOS, GSH, GSH-Px of serum and hepatic tissue were detected after the last medication. Results The water extracted and alcohol extracted components could cause the level of MDA in serum and liver to increase, the activity of SOD corresponding declined, however the level of NO and NOS increased. In addition, the activity of GSH and GSH-Px declined. All the changes were aggravated in accordance with the enhancement of doses and time extension, and these parameters of all the medication administration groups had obvious difference with those of the blank control group. Conclusion The mechanism of the toxical and side effects on inflammatory mice caused by water and alcohol extract from may be related with the peroxidative damage mechanism.

Key words: different components, toxicity, liver damage mechanism, oxidative damage