Abstract: Objective To analyze the characteristics of iodine contrast induced anaphylactic reaction occurred during percutaneous coronary intervention( PCI) , so as to provide a reference to reduce the risk of its use. Methods By searching the clinical database of Beijing Fuwai Cardiovascular Hospital, we retrospectively investigated the incidence of iodine contrast induced anaphylactic reaction during PCI, including coronary angiography, in recent 5 years. We described the relationships between the use of the agent and gender, age, clinical manifestation, and the type of the agent, respectively. Results In all of the 79 102 patients who received PCI , 48 patients ( 0.061 % ) ended up with anaphylactic reaction. Among them, 44(0.056% ) patients were males and 4(0.02% ) patients were females. The ratio between male and female was 11:1. Some commonly used non -ion iodinated agents including iohexol, ioversol, iopamidol, iodixanol and iopromide were involved, iopromide and iodixanol induced most of the anaphylactic reaction. The clinical manifestation of the anaphylactic reaction varied broadly, in which rash was the most commonly observed and shock was the severest drug adverse reaction. Two patients eventually died of severe anaphylactic reaction. Conclusion In general, non-ion iodinated contrast is safe to use in PCI. However, it is still necessary to carefully monitor the occurrence of its anaphylactic reaction. Early recognition and intervention of its manifestation is very critical to improve the safety of both drug use and PCI.