Adverse Drug Reactions Induced by Parabens Used as Preservatives

Abstract

Abstract: Objective To review the adverse drug reactions induced by parabens when used as preservatives. MethodsA simple conclusion on adverse drug reactions induced by parabens was carried out by reviewing the related references. ResultsParabens are the most commonly used preservatives. Parabens are likely to cause adverse reactions as allergic reactions, cross reactions and estrogenic activity, paraben paradox can also be observed. ConclusionProfessional clinicians must pay high attention to the adverse reactions of parabens contained in the pharmaceutical products and use them rationally as possible as they can.

Key words: parabens, allergic reaction, cross reaction, paraben paradox, estrogenic activity

LI Zhong-dong, ZHANG Yun-xuan, GUO Yan-ping, SHI Xiao-jin, ZHONG Ming-kang. Adverse Drug Reactions Induced by Parabens Used as Preservatives[J]. Chinese Journal of Pharmacovigilance, 2012, 9(5): 303-305.

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