Research Development on Chemical Composition in Rhizoma Menispermi Related with Efficacy and Toxicity

Abstract

Abstract: Objective To identify its effective and toxical composition, offer the accordance and research ideas for further research on the relationship between efficacy, toxicity and chemical composition of Rhizoma Menispermi, by summarizing the current states of chemical composition of Rhizoma Menispermi related with its efficacy and toxicity. Methods The related literatures in the recent 20 years of Rhizoma Menispermi were collated, analyzed and summarized. Results Alkaloids are both the main chemical constituents and the main material basis for efficacy in Rhizoma Menispermi; Rhizoma Menispermi has small toxicity documented in pharmacopoeia and history literature, there have little perfect study reports about Rhizoma Menispermi chemical constituents, especially alkaloid standard toxicity. It is still blank for efficacy and toxicity substances in the body process, pharmacological mechanism and characteristics, and clinical application of correlation. The research for its basis of extraction and separation technology research and quality control are also seldom-reported. Conclusion As a small toxical records of TCM, Rhizoma Menispermi is urgent to be studied, based on the efficacy and chemicals related basic and "keep- efficacy" and "control- toxicity" research to provide experimental basement and literature reference for rational use in clinic.

Key words: Rhizoma Menispermi, efficacy, toxicity, chemical composition

LUO Dong, LI Xiao-yu, SUN Rong. Research Development on Chemical Composition in Rhizoma Menispermi Related with Efficacy and Toxicity[J]. Chinese Journal of Pharmacovigilance, 2012, 9(4): 230-233.

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