Study on the Maternal Exposure during Pregnancy and Infantile Hemangioma

Abstract

Abstract: Objective To explore the possible factors for infantile hemangiomas(IHs) with a focus on maternal exposure during pregnancy. MethodsA retrospective analysis was carried out on the neonatal mothers who gave birth to from January 1, 2010 to June 30, 2011 when they presented to the postpartum. All of them were invited to complete a questionnaire including maternal life history, diseases, drug administration and supplementation of multivitamin during pregnancy. Comparison of the maternal factors between the suffered and normal neonate group was conducted by using logistic regression analysis. ResultsDetail information of a total of 953 mothers was collected and 34 of infants were found developing IHs. The results revealed that the advanced maternal age, baby gender, progesterone and over-supplementation of multivitamin(Wald χ2 were 4.932、5.592、5.065、7.585 respectively, P value 0.026、0.018、0.024、0.006 respectively) were the potential factors for developing IHs while no significant difference was found in the paternal age, fever, upper respiratory infection and the administration of Traditional Chinese Medicine(All P value >0.05). ConclusionBesides the advanced maternal age and baby gender as reported in foreign study, our study suggests that progesterone and over-supplementation of multivitamin may be possible factors for developing IHs.

Key words: infantile hemangiomas, risk factor, progesterone, over-supplementation of multivitamin

WANG Lin, MI Shuang-li, CHEN Jie, LIU Fang, LI Ying-chun, GUO Cai-hong, ZHANG Yong, FANG Qin-ying. Study on the Maternal Exposure during Pregnancy and Infantile Hemangioma[J]. Chinese Journal of Pharmacovigilance, 2012, 9(3): 140-143.

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