Chinese Journal of Pharmacovigilance ›› 2012, Vol. 9 ›› Issue (1): 7-8.

• Orginal Article • Previous Articles     Next Articles

Comparing the Toxicity of Valproate Sodium with Divalproex Sodium

HUANG Feng-jiao1, LI Ji-hong1, TANG Dun-li2, JIA Zi-ming1   

  1. 1 Hubei Provincial Institute of Pharmaceutical Industry CO., LTD., Hubei Wuhan 430061, China;
    2 Hunan Province Xiangzhong Pharmaceutical CO.,LTD., Hunan Shaoyang 422000, China
  • Received:2011-08-29 Online:2012-01-10 Published:2015-08-10

PDF (PC)

141

Abstract: Objective To compare the toxicity of Valproate sodium with Divalproex sodium． MethodsRespectively administered different dose of Valproate sodium and Divalproex sodium to rats and mice, observed the toxicity symptoms, death and pathological change, and calculated the LD50 of the two kinds of animals. ResultsThe toxicity symptoms and pathological change are similar, but the toxicity symptoms of Valproate sodium is more serious and there are more animal death comparing with Divalproex sodium under the proximate dosage. ConclusionThe toxicity of Valproate sodium is bigger than Divalproex sodium.

Key words: Valproate sodium, Divalproex sodium, toxicity compare, LD50